Suppresion of frequent premature ventricular contractions and improvement of left ventricular function in patients with presumed idiopathic dilated cardiomyopathy

D. F. Duffee, W. K. Shen, H. C. Smith

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Objective: To examine the hypothesis that suppresion of frequent premature ventricular contractions may be associated with improvement in left ventricular function in patients with pressumed idiopathic dilated cardiomyopathy. Design: We conducted a retrospective case study and statistical analysis of the effect of cardiac medical therapy on outcome. Material and Methods: The study population consisted of 14 patients with more than 20,000 premature ventricular contractions in 24 hours recorded by Holter monitoring and associated left ventricular dysfunction (ejection fraction, 40% or less). Clinical characteristics, number of premature ventricular contractions per hour on 24-hour ambulatory Holter monitoring, and ejection fraction based on transthoracic echocardiography were compared before and after cardiac therapeutic intervention. Results: Of the 14 patients, 10 had presumed idiopathic dilated cardiomyopathy, and 4 had ischemic heart disease. Of the overall study group, seven had received additional cardiac medical after the index evaluation, including four patients who had amiodarone therapy. A significant reduction (75% or more from baseline) in premature ventricular contractions after medical therapeutic intervention was observed in five patients at the first follow-up examination. The mean interval to the first follow-up examination was 6 ± 3 months. Of the five patients, four had significant improvement in clinical functional status and the ejection fraction. The mean ejection fraction of these five patients increased from 27 ± 10% at baseline to 49 ± 17% after medical therapy (P=0.04). Conclusion: The suppresion of frequent premature ventricular contractions may be associated with improvement of left ventricular fucntion in patients with pressumed idiopathic dilated cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)430-433
Number of pages4
JournalMayo Clinic Proceedings
Volume73
Issue number5
StatePublished - 1998

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Ventricular Premature Complexes
Dilated Cardiomyopathy
Left Ventricular Function
Ambulatory Electrocardiography
Therapeutics
Ambulatory Monitoring
Amiodarone
Left Ventricular Dysfunction
Stroke Volume
Myocardial Ischemia
Echocardiography
Retrospective Studies

ASJC Scopus subject areas

  • Medicine(all)

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Suppresion of frequent premature ventricular contractions and improvement of left ventricular function in patients with presumed idiopathic dilated cardiomyopathy. / Duffee, D. F.; Shen, W. K.; Smith, H. C.

In: Mayo Clinic Proceedings, Vol. 73, No. 5, 1998, p. 430-433.

Research output: Contribution to journalArticle

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