Support for RGS4 as a susceptibility gene for schizophrenia

Nigel M. Williams, Anna Preece, Gillian Spurlock, Nadine Norton, Hywel J. Williams, Robin G. McCreadie, Paul Buckland, Val Sharkey, Kodavali V. Chowdari, Stanley Zammit, Vishwajit Nimgaonkar, George Kirov, Michael J. Owen, Michael C. O'Donovan

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

Background The gene encoding the regulator of G-protein signaling 4 has recently been associated with susceptibility to schizophrenia. This finding is particularly interesting, because it was replicated within the same study and also because there are functional, positional, and expression data to support the regulator of G-protein signaling 4 as a schizophrenia candidate gene. Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples. Methods We have examined a large case (n = 709) control (n = 710) sample for association between schizophrenia using four markers investigated in the earlier study, denoted single nucleotide polymorphisms 1, 4, 7, and 18. Results We were able to replicate the associations with single nucleotide polymorphisms 4 and 18 that had previously been reported individually and have also identified significant association with haplotypes constructed from single nucleotide polymorphisms 1 and 4. Conclusions Our data give modest support for the hypothesis that the regulator of G-protein signaling 4 is a susceptibility gene for schizophrenia.

Original languageEnglish (US)
Pages (from-to)192-195
Number of pages4
JournalBiological psychiatry
Volume55
Issue number2
DOIs
StatePublished - Jan 15 2004

Keywords

  • Association
  • Candidate gene
  • Haplotype
  • Promoter
  • Reporter gene
  • Schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry

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  • Cite this

    Williams, N. M., Preece, A., Spurlock, G., Norton, N., Williams, H. J., McCreadie, R. G., Buckland, P., Sharkey, V., Chowdari, K. V., Zammit, S., Nimgaonkar, V., Kirov, G., Owen, M. J., & O'Donovan, M. C. (2004). Support for RGS4 as a susceptibility gene for schizophrenia. Biological psychiatry, 55(2), 192-195. https://doi.org/10.1016/j.biopsych.2003.11.002