Supplementation of ascorbic acid and α-tocopherol prevents arsenic-induced protein oxidation and DNA damage induced by arsenic in rats

R. Kadirvel, K. Sundaram, S. Mani, S. Samuel, N. Elango, C. Panneerselvam

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Contamination of arsenic in drinking water is associated with several human diseases including cancer. It has been reported that oxidative stress plays a vital role in arsenic-induced biochemical and molecular alterations. The aim of the present study was to improve the understanding of arsenic-induced oxidative damage to proteins and to DNA and the role of antioxidants such as ascorbic acid and α-tocopherol in alleviating arsenic-induced damages in experimental rats. A significant increase in the levels of protein oxidation, DNA strand breaks, and DNA-protein cross-links was observed in blood, liver, and kidney of rats exposed to arsenic (100 ppm in drinking water) for 30 days. Co-administration of ascorbic acid and α-tocopherol to arsenic-exposed rats showed a substantial reduction in the levels of arsenic-induced oxidative products of protein and DNA. The results of this study support that free radical-mediated toxic manifestations of arsenic and also suggest that ascorbic acid and α-tocopherol supplementation can improve the arsenic-induced molecular alterations.

Original languageEnglish (US)
Pages (from-to)939-946
Number of pages8
JournalHuman and Experimental Toxicology
Volume26
Issue number12
DOIs
StatePublished - Jan 1 2007

Keywords

  • DNA damage
  • antioxidants
  • arsenic
  • oxidative stress
  • protein oxidation

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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