Supine exercise electrocardiography compared with exercise radionuclide angiography in noninvasive identification of severe coronary artery disease

Raymond J Gibbons, A. R. Zinsmeister, T. D. Miller, I. P. Clements

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Study objective: To determine the incremental value of exercise radionuclide angiography for identification of severe coronary artery disease. Design: Retrospective analysis comparing logistic regression models. Setting: A tertiary care referral center. Patients: Three hundred and ninety-one consecutive patients who had normal resting electrocardiograms (ECGs) and no digoxin therapy within the previous week. Measurements and main results: The exercise ECG model, consisting of magnitude of ST depression, exercise heart rate, and patient gender, was highly predictive of three vessel or left main coronary artery disease (χ2 = 100, P < 0.0001). The model correctly classified 60% of the study group which included 56 patients with and 179 without severe disease. The addition of radionuclide angiographic variables improved the predictive power of the model (χ2 = 124, P < 0.0001). However, the exercise radionuclide angiographic variables increased the number of patients who were correctly classified by only 11 and the percentage by 3% (to a total of 63% of the study group). Conclusions: The modest additional advantage provided by exercise radionuclide angiography for identification of three vessel or left main coronary artery disease in patients with normal resting ECGs would not appear to justify its routine use for this purpose. Before this conclusion is used as a guide for clinical practice, our results should be prospectively confirmed in a separate sample of patients in another institution.

Original languageEnglish (US)
Pages (from-to)743-749
Number of pages7
JournalAnnals of Internal Medicine
Volume112
Issue number10
StatePublished - 1990

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Radionuclide Angiography
Coronary Artery Disease
Electrocardiography
Exercise
Tertiary Care Centers
Radioisotopes
Logistic Models
Digoxin
Heart Rate

ASJC Scopus subject areas

  • Medicine(all)

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Supine exercise electrocardiography compared with exercise radionuclide angiography in noninvasive identification of severe coronary artery disease. / Gibbons, Raymond J; Zinsmeister, A. R.; Miller, T. D.; Clements, I. P.

In: Annals of Internal Medicine, Vol. 112, No. 10, 1990, p. 743-749.

Research output: Contribution to journalArticle

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