Superoxide in the vascular system

Michael S. Wolin, Sachin A. Gupte, Richard A. Oeckler

Research output: Contribution to journalReview articlepeer-review

101 Scopus citations


Oxidant production and regulation is becoming increasingly important in the study of vascular signaling mechanisms, and recent reviews have characterized some of the possible roles for known downstream products of superoxide formation. In this review, we will examine current research in the field, with a special emphasis on the role of the superoxide molecule itself and its place amongst the slightly better understood roles of peroxide and peroxynitrite. The regulatory roles of oxidant species are wide-ranging, and their involvement in processes ranging from intracellular and receptor signaling mechanisms that regulate endothelial mediator release and vascular contractile function to processes that control cellular growth and apoptosis has been implied. Cellular sources of superoxide production and metabolism and the chemical interaction of oxidant species with specific components of cellular signaling mechanisms are considered important factors which determine physiological responses that control vascular function.

Original languageEnglish (US)
Pages (from-to)191-207
Number of pages17
JournalJournal of Vascular Research
Issue number3
StatePublished - 2002


  • Endothelium
  • Nitric oxide
  • Oxidant signaling
  • Peroxide
  • Peroxynitrite
  • Redox signaling
  • Superoxide
  • Vascular function

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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