Super enhancers–new analyses and perspectives on the low hanging fruit

Feda H. Hamdan, Steven Johnsen

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Significant attention has recently been given to a class of enhancers termed “super enhancers”, while implying that “typical enhancers” are less important. In this report, we examine criteria for identification of super enhancers and address the need to evaluate the differences between BRD4-occupied “typical” and “super” enhancers.

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalTranscription
Volume9
Issue number2
DOIs
StatePublished - Mar 15 2018
Externally publishedYes

Keywords

  • BRD4
  • enhancer RNA
  • ERα activation
  • ROSE algorithm
  • super enhancers
  • transcriptional regulation
  • typical enhancers

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics

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