1H MR spectroscopy in common dementias

Kejal M Kantarci, Ronald Carl Petersen, Bradley F Boeve, David S Knopman, D. F. Tang-Wai, P. C. O'Brien, S. D. Weigand, S. D. Edland, G. E. Smith, R. J. Ivnik, Tanis Jill Ferman, Eric George Tangalos, Clifford R Jr. Jack

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Abstract

Objective: To determine the 1H MR spectroscopic (MRS) findings and intergroup differences among common dementias: Alzheimer disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Methods: The authors consecutively recruited 206 normal elderly subjects and 121 patients with AD, 41 with FTLD, 20 with DLB, and 8 with VaD. The 1H MRS metabolite ratio changes in common dementias were evaluated with respect to normal and also differences among the common dementias. Results: N-Acetylaspartate (NAA)/ creatine (Cr) was lower than normal in patients with AD, FTLD, and VaD. Myo-inositol (mI)/Cr was higher than normal in patients with AD and FTLD. Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB. There were no metabolite differences between patients with AD and FTLD or between patients with DLB and VaD. NAA/Cr was lower in patients with AD and FTLD than DLB. MI/Cr was higher in patients with AD and FTLD than VaD. NAA/Cr was also higher in patients with FTLD than DLB. Conclusions: NAA/Cr levels are decreased in dementias that are characterized by neuron loss, such as AD, FTLD, and VaD. MI/Cr levels are elevated in dementias that are pathologically characterized by gliosis, such as AD and FTLD. Cho/Cr levels are elevated in dementias that are characterized by a profound cholinergic deficit, such as AD and DLB.

Original languageEnglish (US)
Pages (from-to)1393-1398
Number of pages6
JournalNeurology
Volume63
Issue number8
StatePublished - Oct 26 2004

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Frontotemporal Lobar Degeneration
Dementia
Creatine
Alzheimer Disease
Magnetic Resonance Spectroscopy
Lewy Body Disease
Vascular Dementia
Choline
Lewy Bodies
Gliosis
Inositol
Cholinergic Agents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

1H MR spectroscopy in common dementias. / Kantarci, Kejal M; Petersen, Ronald Carl; Boeve, Bradley F; Knopman, David S; Tang-Wai, D. F.; O'Brien, P. C.; Weigand, S. D.; Edland, S. D.; Smith, G. E.; Ivnik, R. J.; Ferman, Tanis Jill; Tangalos, Eric George; Jack, Clifford R Jr.

In: Neurology, Vol. 63, No. 8, 26.10.2004, p. 1393-1398.

Research output: Contribution to journalArticle

Kantarci, KM, Petersen, RC, Boeve, BF, Knopman, DS, Tang-Wai, DF, O'Brien, PC, Weigand, SD, Edland, SD, Smith, GE, Ivnik, RJ, Ferman, TJ, Tangalos, EG & Jack, CRJ 2004, '1H MR spectroscopy in common dementias', Neurology, vol. 63, no. 8, pp. 1393-1398.
Kantarci KM, Petersen RC, Boeve BF, Knopman DS, Tang-Wai DF, O'Brien PC et al. 1H MR spectroscopy in common dementias. Neurology. 2004 Oct 26;63(8):1393-1398.
Kantarci, Kejal M ; Petersen, Ronald Carl ; Boeve, Bradley F ; Knopman, David S ; Tang-Wai, D. F. ; O'Brien, P. C. ; Weigand, S. D. ; Edland, S. D. ; Smith, G. E. ; Ivnik, R. J. ; Ferman, Tanis Jill ; Tangalos, Eric George ; Jack, Clifford R Jr. / 1H MR spectroscopy in common dementias. In: Neurology. 2004 ; Vol. 63, No. 8. pp. 1393-1398.
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abstract = "Objective: To determine the 1H MR spectroscopic (MRS) findings and intergroup differences among common dementias: Alzheimer disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Methods: The authors consecutively recruited 206 normal elderly subjects and 121 patients with AD, 41 with FTLD, 20 with DLB, and 8 with VaD. The 1H MRS metabolite ratio changes in common dementias were evaluated with respect to normal and also differences among the common dementias. Results: N-Acetylaspartate (NAA)/ creatine (Cr) was lower than normal in patients with AD, FTLD, and VaD. Myo-inositol (mI)/Cr was higher than normal in patients with AD and FTLD. Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB. There were no metabolite differences between patients with AD and FTLD or between patients with DLB and VaD. NAA/Cr was lower in patients with AD and FTLD than DLB. MI/Cr was higher in patients with AD and FTLD than VaD. NAA/Cr was also higher in patients with FTLD than DLB. Conclusions: NAA/Cr levels are decreased in dementias that are characterized by neuron loss, such as AD, FTLD, and VaD. MI/Cr levels are elevated in dementias that are pathologically characterized by gliosis, such as AD and FTLD. Cho/Cr levels are elevated in dementias that are characterized by a profound cholinergic deficit, such as AD and DLB.",
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AU - Petersen, Ronald Carl

AU - Boeve, Bradley F

AU - Knopman, David S

AU - Tang-Wai, D. F.

AU - O'Brien, P. C.

AU - Weigand, S. D.

AU - Edland, S. D.

AU - Smith, G. E.

AU - Ivnik, R. J.

AU - Ferman, Tanis Jill

AU - Tangalos, Eric George

AU - Jack, Clifford R Jr.

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N2 - Objective: To determine the 1H MR spectroscopic (MRS) findings and intergroup differences among common dementias: Alzheimer disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Methods: The authors consecutively recruited 206 normal elderly subjects and 121 patients with AD, 41 with FTLD, 20 with DLB, and 8 with VaD. The 1H MRS metabolite ratio changes in common dementias were evaluated with respect to normal and also differences among the common dementias. Results: N-Acetylaspartate (NAA)/ creatine (Cr) was lower than normal in patients with AD, FTLD, and VaD. Myo-inositol (mI)/Cr was higher than normal in patients with AD and FTLD. Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB. There were no metabolite differences between patients with AD and FTLD or between patients with DLB and VaD. NAA/Cr was lower in patients with AD and FTLD than DLB. MI/Cr was higher in patients with AD and FTLD than VaD. NAA/Cr was also higher in patients with FTLD than DLB. Conclusions: NAA/Cr levels are decreased in dementias that are characterized by neuron loss, such as AD, FTLD, and VaD. MI/Cr levels are elevated in dementias that are pathologically characterized by gliosis, such as AD and FTLD. Cho/Cr levels are elevated in dementias that are characterized by a profound cholinergic deficit, such as AD and DLB.

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