1H MR spectroscopy in common dementias

K. Kantarci, R. C. Petersen, B. F. Boeve, D. S. Knopman, D. F. Tang-Wai, P. C. O'Brien, S. D. Weigand, S. D. Edland, G. E. Smith, R. J. Ivnik, T. J. Ferman, E. G. Tangalos, C. R. Jack

Research output: Contribution to journalArticle

189 Scopus citations

Abstract

Objective: To determine the 1H MR spectroscopic (MRS) findings and intergroup differences among common dementias: Alzheimer disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Methods: The authors consecutively recruited 206 normal elderly subjects and 121 patients with AD, 41 with FTLD, 20 with DLB, and 8 with VaD. The 1H MRS metabolite ratio changes in common dementias were evaluated with respect to normal and also differences among the common dementias. Results: N-Acetylaspartate (NAA)/ creatine (Cr) was lower than normal in patients with AD, FTLD, and VaD. Myo-inositol (mI)/Cr was higher than normal in patients with AD and FTLD. Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB. There were no metabolite differences between patients with AD and FTLD or between patients with DLB and VaD. NAA/Cr was lower in patients with AD and FTLD than DLB. MI/Cr was higher in patients with AD and FTLD than VaD. NAA/Cr was also higher in patients with FTLD than DLB. Conclusions: NAA/Cr levels are decreased in dementias that are characterized by neuron loss, such as AD, FTLD, and VaD. MI/Cr levels are elevated in dementias that are pathologically characterized by gliosis, such as AD and FTLD. Cho/Cr levels are elevated in dementias that are characterized by a profound cholinergic deficit, such as AD and DLB.

Original languageEnglish (US)
Pages (from-to)1393-1398
Number of pages6
JournalNeurology
Volume63
Issue number8
DOIs
StatePublished - Oct 26 2004

ASJC Scopus subject areas

  • Clinical Neurology

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