1H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults

Firat Kara, James M. Joers, Dinesh K. Deelchand, Young Woo Park, Scott A. Przybelski, Timothy G. Lesnick, Matthew L. Senjem, Burcu Zeydan, David S. Knopman, Val J. Lowe, Prashanthi Vemuri, Michelle M. Mielke, Mary M. Machulda, Clifford R. Jack, Ronald C. Petersen, Gülin Öz, Kejal Kantarci

Research output: Contribution to journalArticlepeer-review

Abstract

Proton magnetic resonance spectroscopy (1H MRS) may provide information on pathophysiological changes associated with tau deposition in cognitively unimpaired older adults. In this study, the associations of posterior cingulate gyrus tau and amyloid beta (Aβ) deposition on PET with 1H MRS metabolite ratios acquired from bilateral posterior cingulate gyri were investigated in cognitively unimpaired older adults. Participants (n = 40) from the Mayo Clinic Study of Aging underwent single-voxel sLASER 1H MRS from the posterior cingulate gyrus at 3 Tesla, 18F-flortaucipir, and 11C- Pittsburgh Compound B (PiB) PET. An increase in posterior cingulate gyrus tau deposition, but not elevated Aβ, was associated with lower N-acetylaspartate/total creatine (tCr) and glutamate (Glu)/tCr ratios, and sex by tau interaction was observed in association with Glu/tCr. Higher tau levels in cognitively unimpaired older adults are associated with biomarkers of neural and synaptic injury even in the absence of cognitive impairment and these relationships appear to be stronger in women than in men.

Original languageEnglish (US)
Pages (from-to)16-26
Number of pages11
JournalNeurobiology of aging
Volume112
DOIs
StatePublished - Apr 2022

Keywords

  • Amyloid-beta
  • Glutamate
  • N-acetylaspartate
  • Positron emission tomography
  • Proton magnetic resonance spectroscopy
  • Sex differences
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology

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