18O-assisted dynamic metabolomics for individualized diagnostics and treatment of human diseases

Emirhan Nemutlu, Song Zhang, Nenad O. Juranic, Andre Terzic, Slobodan Macura, Petras Dzeja

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Technological innovations and translation of basic discoveries to clinical practice drive advances in medicine. Today's innovative technologies enable comprehensive screening of the genome, transcriptome, proteome, and metabolome. The detailed knowledge, converged in the integrated "omics" (genomics, transcriptomics, proteomics, and metabolomics), holds an immense potential for understanding mechanism of diseases, facilitating their early diagnostics, selecting personalized therapeutic strategies, and assessing their effectiveness. Metabolomics is the newest "omics" approach aimed to analyze large metabolite pools. The next generation of metabolomic screening requires technologies for high throughput and robust monitoring of metabolite levels and their fluxes. In this regard, stable isotope 18O-based metabolite tagging technology expands quantitative measurements of metabolite levels and turnover rates to all metabolites that include water as a reactant, most notably phosphometabolites. The obtained profiles and turnover rates are sensitive indicators of energy and metabolic imbalances like the ones created by genetic deficiencies, myocardial ischemia, heart failure, neurodegenerative disorders, etc. Here we describe and discuss briefly the potential use of dynamic phosphometabolomic platform for disease diagnostics currently under development at Mayo Clinic.

Original languageEnglish (US)
Pages (from-to)529-534
Number of pages6
JournalCroatian Medical Journal
Volume53
Issue number6
DOIs
StatePublished - Dec 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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