Summary of contributions to GAW15 Group 13

Candidate gene association studies

Mariza De Andrade, Andrew S. Allen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Here we summarize the contributions to Group 13 of the Genetic Analysis Workshop 15 held in St. Pete Beach, Florida, on November 12-14, 2006. The focus of this group was to identify candidate genes associated with rheumatoid arthritis or surrogate outcomes. The association methods proposed in this group were diverse, from better known approaches, such as logistic regression for single nucleotide polymorphism (SNP) analysis and haplotype sharing tests to methods less familiar to genetic epidemiologists, such as machine learning and visualization methods. The majority of papers analyzed Genetic Analysis Workshop 15 Problems 2 (rheumatoid arthritis data) and 3 (simulated data). The highlighted points of this group analyses were: (1) haplotype-based statistics can be more powerful than single SNP analysis for risk-locus localization; (2) considering linkage disequilibrium block structure in haplotype analysis may reduce the likelihood of false-positive results; and (3) visual representation of genetic models for continuous covariates may help identify SNPs associated with the underlying quantitative trait loci.

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume31
Issue numberSUPPL. 1
DOIs
StatePublished - 2007

Fingerprint

Genetic Association Studies
Haplotypes
Single Nucleotide Polymorphism
Rheumatoid Arthritis
Education
Quantitative Trait Loci
Genetic Models
Linkage Disequilibrium
Focus Groups
Logistic Models
Genes

Keywords

  • Epistasis
  • Haplotype sharing
  • Single SNP

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Summary of contributions to GAW15 Group 13 : Candidate gene association studies. / De Andrade, Mariza; Allen, Andrew S.

In: Genetic Epidemiology, Vol. 31, No. SUPPL. 1, 2007.

Research output: Contribution to journalArticle

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