Summary of contributions to GAW Group 12: Multivariate methods

Mariza De Andrade, Nancy R. Mendell

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Here we summarize the contributions to Group 12 of Genetic Analysis Workshop (GAW) 14, held in Noordwijkerhout, The Netherlands. The theme of this group, multivariate methods, covered a broad range of statistical applications. Most of the contributors considered Problem 1 of the GAW. However, one paper considered the bivariate analysis of two binary phenotypes generated by the simulated data in Problem 2. Some contributors focused on statistical issues involved in considering multiple variables, and others on extensions to the variance-components methodology for analysis of quantitative traits. Applications to the Collaborative Study on the Genetics of Alcoholism data identified a single-nucleotide polymorphism (SNP) on chromosome 4 associated with the ttth1-ttth4 phenotypes, and replicated previous findings of linkage on chromosome 4 for alcohol consumption, using microsatellite and SNP data.

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume29
Issue numberSUPPL.
DOIs
StatePublished - 2005

Fingerprint

Chromosomes, Human, Pair 4
Single Nucleotide Polymorphism
Phenotype
Education
Alcohol Drinking
Netherlands
Microsatellite Repeats
Alcoholism

Keywords

  • LOD score
  • Multivariate analysis
  • Variance components

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

Cite this

Summary of contributions to GAW Group 12 : Multivariate methods. / De Andrade, Mariza; Mendell, Nancy R.

In: Genetic Epidemiology, Vol. 29, No. SUPPL., 2005.

Research output: Contribution to journalArticle

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