Sugar-sweetened beverage intake and the risk of type I and type II endometrial cancer among postmenopausal women

Maki Inoue-Choi, Kim Robien, Andrea Mariani, James R Cerhan, Kristin E. Anderson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Sugar-sweetened beverage (SSB) intake has been associated with an increased risk of obesity and type II diabetes. However, its association with endometrial cancer is unclear. Methods: We evaluated dietary intake of SSB, fruit juice, sugar-free beverages, sweets/baked goods, starch, and sugars among 23,039 postmenopausal women in the Iowa Women's Health Study. Incident estrogen-dependent type I and estrogen-independent type II endometrial cancers were identified via linkage with the Surveillance Epidemiology and End Results Registry. Risks of type I and type II endometrial cancers were separately compared by energy-adjusted dietary intake in Cox proportional hazards regression models. Results: From 1986 to 2010, 506 type I and 89 type II incident endometrial cancers were identified. An increased risk of type I endometrial cancer was observed with increasing SSB intake after adjustment for body mass index (BMI) and other cofounders (Ptrend=0.0005). Compared with nondrinkers of SSB, the risk was 78% higher [95% confidence intervals (CI), 1.32-2.40] among women in the highest quintile of SSB intake. The observed association was not modified by BMI, physical activity, history of diabetes, or cigarette smoking. Higher risk of type I endometrial cancer was also observed with higher intake of sugars. None of the dietary items included in the analysis was associated with type II endometrial cancer risk. Conclusion: Higher intake of SSB and sugars was associated with an increased risk of type I, but not type II, endometrial cancer. Impact: SSB intake may be a risk factor for type I endometrial cancer regardless of other lifestyle factors.

Original languageEnglish (US)
Pages (from-to)2384-2394
Number of pages11
JournalCancer Epidemiology Biomarkers and Prevention
Volume22
Issue number12
DOIs
StatePublished - Dec 2013

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Beverages
Endometrial Neoplasms
Estrogens
Body Mass Index
Dietary Sucrose
Women's Health
Proportional Hazards Models
Starch
Type 2 Diabetes Mellitus
Registries
Life Style
Epidemiology
Obesity
Smoking
Confidence Intervals
Exercise

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Sugar-sweetened beverage intake and the risk of type I and type II endometrial cancer among postmenopausal women. / Inoue-Choi, Maki; Robien, Kim; Mariani, Andrea; Cerhan, James R; Anderson, Kristin E.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 22, No. 12, 12.2013, p. 2384-2394.

Research output: Contribution to journalArticle

Inoue-Choi, Maki ; Robien, Kim ; Mariani, Andrea ; Cerhan, James R ; Anderson, Kristin E. / Sugar-sweetened beverage intake and the risk of type I and type II endometrial cancer among postmenopausal women. In: Cancer Epidemiology Biomarkers and Prevention. 2013 ; Vol. 22, No. 12. pp. 2384-2394.
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