Utilisation de sugammadex chez les patients atteints d’insuffisance rénale terminale: une étude de cohorte historique

Translated title of the contribution: Sugammadex use in patients with end-stage renal disease: a historical cohort study

Stephania Paredes, Steven B. Porter, Ivan E. Porter, J. Ross Renew

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Purpose: While sugammadex (SGX) is not approved for use in patients with end-stage renal disease (ESRD), its administration in this patient population has been reported. We designed the current study to review all instances of patients with ESRD receiving SGX and to describe their clinical outcomes. Methods: This is a historical cohort study of 219 patients with chronic kidney disease stage 5 who received SGX in one of three hospital locations within the same academic health system. Data were collected between 7 March 2016 and 1 August 2019 and included demographics, notable events from the anesthesia records, and postoperative complications. The primary outcome included any complication possibly related to SGX such as hypersensitivity reactions, need for reintubation, hypoxemia, pneumonia, and residual neuromuscular blockade. Secondary outcomes included any other complication not included in the primary outcome and/or patient mortality within 30 days after the procedure. Results: No patient experienced a hypersensitivity reaction. Three patients required reintubation while two patients developed hypoxemia that did not require reintubation. One patient developed hospital-acquired pneumonia. Fifty (23%) patients developed other postoperative complications (different from our primary outcome) and nine patients (4%) died during the subsequent 30 postoperative days. None of the primary or secondary outcomes appeared to be related to SGX use. Conclusions: We provide incremental evidence that SGX could be considered as an alternative neuromuscular blockade reversal agent in patients with ESRD.

Translated title of the contributionSugammadex use in patients with end-stage renal disease: a historical cohort study
Original languageFrench
Pages (from-to)1789-1797
Number of pages9
JournalCanadian Journal of Anesthesia
Volume67
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • chronic kidney disease
  • end-stage renal disease
  • neuromuscular blockade
  • patient safety
  • sugammadex

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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