Sudden infant death syndrome: How significant are the cardiac channelopathies?

David J. Tester, Michael J. Ackerman

Research output: Contribution to journalReview article

152 Scopus citations

Abstract

Having an apparently healthy, thriving infant fail to reach his/her first birthday is profoundly tragic. This tragedy is compounded when the infant's death is unexpected and unexplained, signed out as sudden infant death syndrome (SIDS). Despite impressive success and welcome reductions in these tragic deaths due in large measure to "Back-to-Sleep" campaigns, the fundamental pathogenic mechanisms precipitating such deaths remain dimly exposed. Here, we review the causal link between SIDS and mutations involving the SCN5A-encoded cardiac sodium channel, provide new findings following extensive postmortem genetic testing of long QT syndrome (LQTS)-associated potassium channel genes in a population-based cohort of SIDS, and summarize the current understanding regarding the spectrum and prevalence of cardiac channelopathies in the pathogenesis of SIDS.

Original languageEnglish (US)
Pages (from-to)388-396
Number of pages9
JournalCardiovascular research
Volume67
Issue number3
DOIs
StatePublished - Aug 15 2005

Keywords

  • Arrhythmias
  • Forensic science
  • Ion channels
  • Long QT syndrome
  • Sudden infant death syndrome

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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