Sudden death in septo-optic dysplasia: Report of 5 cases

Michael C Brodsky, Felix A. Conte, David Taylor, Creig S. Hoyt, Robert E. Mrak

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Objectives: To report our experience with sudden death in children with septo-optic dysplasia and to identity specific risk factors and suggest preventive measures to minimize mortality. Methods: Clinical data from 5 children with septo-optic dysplasia who died suddenly and unexpectedly were evaluated retrospectively. Results: All children had corticotropin deficiency, all had thermoregulatory disturbances, and 4 children had diabetes insipidus. In at least 4 children, clinical deterioration was caused by lever and dehydration from a presumed viral illness, which appeared to precipitate adrenal crisis. Conclusions: Children with septo-optic dysplasia and hypocortisolism are at risk for sudden death during febrile illness. Thermoregulatory disturbances and dehydration from diabetes insipidus may potentiate clinical deterioration. Prevention of sudden death in septo-optic dysplasia requires early recognition and treatment of these major risk factors.

Original languageEnglish (US)
Pages (from-to)66-70
Number of pages5
JournalArchives of Ophthalmology
Volume115
Issue number1
StatePublished - 1997
Externally publishedYes

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Septo-Optic Dysplasia
Sudden Death
Diabetes Insipidus
Dehydration
Adrenocorticotropic Hormone
Fever
Mortality

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Brodsky, M. C., Conte, F. A., Taylor, D., Hoyt, C. S., & Mrak, R. E. (1997). Sudden death in septo-optic dysplasia: Report of 5 cases. Archives of Ophthalmology, 115(1), 66-70.

Sudden death in septo-optic dysplasia : Report of 5 cases. / Brodsky, Michael C; Conte, Felix A.; Taylor, David; Hoyt, Creig S.; Mrak, Robert E.

In: Archives of Ophthalmology, Vol. 115, No. 1, 1997, p. 66-70.

Research output: Contribution to journalArticle

Brodsky, MC, Conte, FA, Taylor, D, Hoyt, CS & Mrak, RE 1997, 'Sudden death in septo-optic dysplasia: Report of 5 cases', Archives of Ophthalmology, vol. 115, no. 1, pp. 66-70.
Brodsky MC, Conte FA, Taylor D, Hoyt CS, Mrak RE. Sudden death in septo-optic dysplasia: Report of 5 cases. Archives of Ophthalmology. 1997;115(1):66-70.
Brodsky, Michael C ; Conte, Felix A. ; Taylor, David ; Hoyt, Creig S. ; Mrak, Robert E. / Sudden death in septo-optic dysplasia : Report of 5 cases. In: Archives of Ophthalmology. 1997 ; Vol. 115, No. 1. pp. 66-70.
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