Sudden death in mitral regurgitation due to flail leaflet

Francesco Grigioni, Maurice E Sarano, Lieng H. Ling, Kent R Bailey, James B. Seward, A. Jamil Tajik, Robert L. Frye

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Abstract

OBJECTIVES: We sought to assess the incidence and determinants of sudden death (SUD) in mitral regurgitation due to flail leaflet (MR-FL). BACKGROUND: Sudden death is a catastrophic complication of MR-FL. Its incidence and predictability are undefined. METHODS: The occurrence of SUD was analyzed in 348 patients (age 67 ± 12 years) with MR-FL diagnosed echocardiographically from 1980 through 1994. RESULTS: During a mean follow-up of 48 ± 41 months, 99 deaths occurred under medical treatment. Sudden death occurred in 25 patients, three of whom were resuscitated. The sudden death rates at five and 10 years were 8.6 ± 2% and 18.8 ± 4%, respectively, and the linearized rate was 1.8% per year. By multivariate analysis, the independent baseline predictors of SUD were New York Heart Association (NYHA) functional class (p = 0.006), ejection fraction (p = 0.0001) and atrial fibrillation (p = 0.059). The yearly linearized rate of sudden death was 1% in patients in functional class I, 3.1% in class II and 7.8% in classes III and IV. However, of 25 patients who had SUD, at baseline, 10 (40%) were in functional class I, 9 (36%) were in class II and only 6 (24%) in class III or IV. In five patients (20%), no evidence of risk factors developed until SUD. In patients with an ejection fraction ≥60% and sinus rhythm, the linearized rate of SUD was not different in functional classes I and II (0.8% per year). Surgical correction of MR (n = 186) was independently associated with a reduced incidence of SUD (adjusted hazard ratio [95% confidence interval] 0.29 [0.11 to 0.72], p = 0.007). CONCLUSIONS: Sudden death is relatively common in patients with MR-FL who are conservatively managed. Patients with severe symptoms, atrial fibrillation and reduced systolic function are at higher risk, but notable rates of SUD have been observed without these risk factors. Correction of MR appears to be associated with a reduced incidence of SUD, warranting early consideration of surgical repair.

Original languageEnglish (US)
Pages (from-to)2078-2085
Number of pages8
JournalJournal of the American College of Cardiology
Volume34
Issue number7
DOIs
StatePublished - Dec 1999

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Mitral Valve Insufficiency
Sudden Death
Incidence
Atrial Fibrillation
Multivariate Analysis

ASJC Scopus subject areas

  • Nursing(all)

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Sudden death in mitral regurgitation due to flail leaflet. / Grigioni, Francesco; Sarano, Maurice E; Ling, Lieng H.; Bailey, Kent R; Seward, James B.; Tajik, A. Jamil; Frye, Robert L.

In: Journal of the American College of Cardiology, Vol. 34, No. 7, 12.1999, p. 2078-2085.

Research output: Contribution to journalArticle

Grigioni, Francesco ; Sarano, Maurice E ; Ling, Lieng H. ; Bailey, Kent R ; Seward, James B. ; Tajik, A. Jamil ; Frye, Robert L. / Sudden death in mitral regurgitation due to flail leaflet. In: Journal of the American College of Cardiology. 1999 ; Vol. 34, No. 7. pp. 2078-2085.
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abstract = "OBJECTIVES: We sought to assess the incidence and determinants of sudden death (SUD) in mitral regurgitation due to flail leaflet (MR-FL). BACKGROUND: Sudden death is a catastrophic complication of MR-FL. Its incidence and predictability are undefined. METHODS: The occurrence of SUD was analyzed in 348 patients (age 67 ± 12 years) with MR-FL diagnosed echocardiographically from 1980 through 1994. RESULTS: During a mean follow-up of 48 ± 41 months, 99 deaths occurred under medical treatment. Sudden death occurred in 25 patients, three of whom were resuscitated. The sudden death rates at five and 10 years were 8.6 ± 2{\%} and 18.8 ± 4{\%}, respectively, and the linearized rate was 1.8{\%} per year. By multivariate analysis, the independent baseline predictors of SUD were New York Heart Association (NYHA) functional class (p = 0.006), ejection fraction (p = 0.0001) and atrial fibrillation (p = 0.059). The yearly linearized rate of sudden death was 1{\%} in patients in functional class I, 3.1{\%} in class II and 7.8{\%} in classes III and IV. However, of 25 patients who had SUD, at baseline, 10 (40{\%}) were in functional class I, 9 (36{\%}) were in class II and only 6 (24{\%}) in class III or IV. In five patients (20{\%}), no evidence of risk factors developed until SUD. In patients with an ejection fraction ≥60{\%} and sinus rhythm, the linearized rate of SUD was not different in functional classes I and II (0.8{\%} per year). Surgical correction of MR (n = 186) was independently associated with a reduced incidence of SUD (adjusted hazard ratio [95{\%} confidence interval] 0.29 [0.11 to 0.72], p = 0.007). CONCLUSIONS: Sudden death is relatively common in patients with MR-FL who are conservatively managed. Patients with severe symptoms, atrial fibrillation and reduced systolic function are at higher risk, but notable rates of SUD have been observed without these risk factors. Correction of MR appears to be associated with a reduced incidence of SUD, warranting early consideration of surgical repair.",
author = "Francesco Grigioni and Sarano, {Maurice E} and Ling, {Lieng H.} and Bailey, {Kent R} and Seward, {James B.} and Tajik, {A. Jamil} and Frye, {Robert L.}",
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T1 - Sudden death in mitral regurgitation due to flail leaflet

AU - Grigioni, Francesco

AU - Sarano, Maurice E

AU - Ling, Lieng H.

AU - Bailey, Kent R

AU - Seward, James B.

AU - Tajik, A. Jamil

AU - Frye, Robert L.

PY - 1999/12

Y1 - 1999/12

N2 - OBJECTIVES: We sought to assess the incidence and determinants of sudden death (SUD) in mitral regurgitation due to flail leaflet (MR-FL). BACKGROUND: Sudden death is a catastrophic complication of MR-FL. Its incidence and predictability are undefined. METHODS: The occurrence of SUD was analyzed in 348 patients (age 67 ± 12 years) with MR-FL diagnosed echocardiographically from 1980 through 1994. RESULTS: During a mean follow-up of 48 ± 41 months, 99 deaths occurred under medical treatment. Sudden death occurred in 25 patients, three of whom were resuscitated. The sudden death rates at five and 10 years were 8.6 ± 2% and 18.8 ± 4%, respectively, and the linearized rate was 1.8% per year. By multivariate analysis, the independent baseline predictors of SUD were New York Heart Association (NYHA) functional class (p = 0.006), ejection fraction (p = 0.0001) and atrial fibrillation (p = 0.059). The yearly linearized rate of sudden death was 1% in patients in functional class I, 3.1% in class II and 7.8% in classes III and IV. However, of 25 patients who had SUD, at baseline, 10 (40%) were in functional class I, 9 (36%) were in class II and only 6 (24%) in class III or IV. In five patients (20%), no evidence of risk factors developed until SUD. In patients with an ejection fraction ≥60% and sinus rhythm, the linearized rate of SUD was not different in functional classes I and II (0.8% per year). Surgical correction of MR (n = 186) was independently associated with a reduced incidence of SUD (adjusted hazard ratio [95% confidence interval] 0.29 [0.11 to 0.72], p = 0.007). CONCLUSIONS: Sudden death is relatively common in patients with MR-FL who are conservatively managed. Patients with severe symptoms, atrial fibrillation and reduced systolic function are at higher risk, but notable rates of SUD have been observed without these risk factors. Correction of MR appears to be associated with a reduced incidence of SUD, warranting early consideration of surgical repair.

AB - OBJECTIVES: We sought to assess the incidence and determinants of sudden death (SUD) in mitral regurgitation due to flail leaflet (MR-FL). BACKGROUND: Sudden death is a catastrophic complication of MR-FL. Its incidence and predictability are undefined. METHODS: The occurrence of SUD was analyzed in 348 patients (age 67 ± 12 years) with MR-FL diagnosed echocardiographically from 1980 through 1994. RESULTS: During a mean follow-up of 48 ± 41 months, 99 deaths occurred under medical treatment. Sudden death occurred in 25 patients, three of whom were resuscitated. The sudden death rates at five and 10 years were 8.6 ± 2% and 18.8 ± 4%, respectively, and the linearized rate was 1.8% per year. By multivariate analysis, the independent baseline predictors of SUD were New York Heart Association (NYHA) functional class (p = 0.006), ejection fraction (p = 0.0001) and atrial fibrillation (p = 0.059). The yearly linearized rate of sudden death was 1% in patients in functional class I, 3.1% in class II and 7.8% in classes III and IV. However, of 25 patients who had SUD, at baseline, 10 (40%) were in functional class I, 9 (36%) were in class II and only 6 (24%) in class III or IV. In five patients (20%), no evidence of risk factors developed until SUD. In patients with an ejection fraction ≥60% and sinus rhythm, the linearized rate of SUD was not different in functional classes I and II (0.8% per year). Surgical correction of MR (n = 186) was independently associated with a reduced incidence of SUD (adjusted hazard ratio [95% confidence interval] 0.29 [0.11 to 0.72], p = 0.007). CONCLUSIONS: Sudden death is relatively common in patients with MR-FL who are conservatively managed. Patients with severe symptoms, atrial fibrillation and reduced systolic function are at higher risk, but notable rates of SUD have been observed without these risk factors. Correction of MR appears to be associated with a reduced incidence of SUD, warranting early consideration of surgical repair.

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