Succinate dehydrogenase loss in familial paraganglioma

Biochemistry, genetics, and epigenetics

Yeng F. Her, L James Maher III

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle. Here we review biochemical, genetic, and epigenetic considerations in succinate dehydrogenase loss and present leading models and mysteries associated with this fascinating and important tumor.

Original languageEnglish (US)
Article number296167
JournalInternational Journal of Endocrinology
Volume2015
DOIs
StatePublished - 2015

Fingerprint

Paraganglioma
Succinate Dehydrogenase
Epigenomics
Biochemistry
Neoplasms
Citric Acid Cycle
Molecular Biology
Adenosine Triphosphate

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

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abstract = "It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle. Here we review biochemical, genetic, and epigenetic considerations in succinate dehydrogenase loss and present leading models and mysteries associated with this fascinating and important tumor.",
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