Successful treatment of recurrent pediatric inflammatory myofibroblastic tumor in a single patient with a novel chemotherapeutic regimen containing celecoxib

Kevin Johnson, David M. Notrica, David Carpentieri, Dawn Jaroszewski, Michael M. Henry

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Inflammatory myofibroblastic tumors are rare tumors characterized as low-to-intermediate grade sarcomas. This is a case of a 7-year-old male with a 5-cm lung mass, which recurred 11 months after complete resection. The recurrence manifested as multifocal metastatic disease involving the ipsilateral parietal and visceral pleura. A novel chemotherapeutic regimen, which included vincristine, ifosfamide, doxorubicin, and celecoxib was utilized for the disease recurrence. The patient had complete and durable remission of the disease and has been disease-free for >4 years. This novel regimen including a cyclooxygenase 2 inhibitor may be an effective regimen for metastatic inflammatory myofibroblastic tumors.

Original languageEnglish (US)
Pages (from-to)414-416
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume35
Issue number5
DOIs
StatePublished - Jul 2013

Fingerprint

Celecoxib
Pediatrics
Pleura
Neoplasms
Recurrence
Ifosfamide
Cyclooxygenase 2 Inhibitors
Vincristine
Therapeutics
Sarcoma
Doxorubicin
Lung

Keywords

  • Cancer pharmacology
  • Celecoxib
  • Inflammatory myofibroblastic tumor (IMT)
  • Metastasis
  • Pediatric lung cancer

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Successful treatment of recurrent pediatric inflammatory myofibroblastic tumor in a single patient with a novel chemotherapeutic regimen containing celecoxib. / Johnson, Kevin; Notrica, David M.; Carpentieri, David; Jaroszewski, Dawn; Henry, Michael M.

In: Journal of Pediatric Hematology/Oncology, Vol. 35, No. 5, 07.2013, p. 414-416.

Research output: Contribution to journalArticle

Johnson, Kevin ; Notrica, David M. ; Carpentieri, David ; Jaroszewski, Dawn ; Henry, Michael M. / Successful treatment of recurrent pediatric inflammatory myofibroblastic tumor in a single patient with a novel chemotherapeutic regimen containing celecoxib. In: Journal of Pediatric Hematology/Oncology. 2013 ; Vol. 35, No. 5. pp. 414-416.
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