TY - JOUR
T1 - Successful treatment of mediastinal lymphomatoid granulomatosis with rituximab monotherapy
AU - Jordan, Karin
AU - Grothey, Axel
AU - Grothe, Wilfried
AU - Kegel, Thomas
AU - Wolf, Hans Heinrich
AU - Schmoll, Hans Joachim
PY - 2005/3
Y1 - 2005/3
N2 - Lymphomatoid granulomatosis is a rare Epstein-Barr virus (EBV)-positive-B-cell lymphoproliferative disorder. Treatment options include corticosteroids, antiviral therapy, interferon-alpha and chemotherapy. However, long-term prognosis is poor and no therapeutic standard has been established yet. In a 21-year-old woman, a biopsy of mediastinal mass revealed lymphomatoid granulomatosis. Combined therapy with valganciclovir and interferon-alpha proved ineffective. In view of the CD20 expression of the tumor cells, monotherapy with rituximab was intiated. After 3 months a complete remission was achieved. Rituximab was continued for another 6 months with subsequent consolidation radiotherapy. This is the first report of an enduring complete remission (20 months) of a non-CNS lymphomatoid granulomatosis treated with rituximab.
AB - Lymphomatoid granulomatosis is a rare Epstein-Barr virus (EBV)-positive-B-cell lymphoproliferative disorder. Treatment options include corticosteroids, antiviral therapy, interferon-alpha and chemotherapy. However, long-term prognosis is poor and no therapeutic standard has been established yet. In a 21-year-old woman, a biopsy of mediastinal mass revealed lymphomatoid granulomatosis. Combined therapy with valganciclovir and interferon-alpha proved ineffective. In view of the CD20 expression of the tumor cells, monotherapy with rituximab was intiated. After 3 months a complete remission was achieved. Rituximab was continued for another 6 months with subsequent consolidation radiotherapy. This is the first report of an enduring complete remission (20 months) of a non-CNS lymphomatoid granulomatosis treated with rituximab.
KW - CD20
KW - EBV-associated lymphoproliferative disease
KW - Liebow granulomatosis
KW - Lymphomatoid granulomatosis
KW - Mediastinal bulk
KW - Rituximab
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U2 - 10.1111/j.1600-0609.2004.00367.x
DO - 10.1111/j.1600-0609.2004.00367.x
M3 - Article
C2 - 15693798
AN - SCOPUS:14044256512
SN - 0902-4441
VL - 74
SP - 263
EP - 266
JO - European Journal of Haematology
JF - European Journal of Haematology
IS - 3
ER -