Successful treatment of JMML relapsed after unrelated allogeneic transplant with cytoreduction followed by DLI and interferon-alpha

Evidence for a graft-versus-leukemia effect in non-monosomy-7 JMML

M. A. Pulsipher, R. H. Adams, J. Asch, F. B. Petersen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Relapse is the major cause of treatment failure after allogeneic transplantation of children with juvenile myelomonocytic leukemia (JMML), and the role of post-transplant immunomodulation is poorly understood. We report a 12-month-old child with JMML relapsed after unrelated marrow transplantation who received cytoreduction followed by donor lymphocyte infusion (DLI) with improvement, and after addition of interferon-alpha (IFN) achieved complete donor chimerism. He was weaned from IFN and has maintained complete remission for 19 months. This is the first published report of a patient with non-monosomy-7 JMML responding to post-transplant immunomodulation and suggests a role for DLI plus IFN in these patients.

Original languageEnglish (US)
Pages (from-to)113-115
Number of pages3
JournalBone Marrow Transplantation
Volume33
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Juvenile Myelomonocytic Leukemia
Interferon-alpha
Leukemia
Immunomodulation
Tissue Donors
Lymphocytes
Transplants
Chimerism
Homologous Transplantation
Treatment Failure
Therapeutics
Transplantation
Bone Marrow
Recurrence

Keywords

  • Allogeneic stem cell transplantation
  • Donor lymphocyte infusion (DLI)
  • Graft-versus-leukemia (GVL)
  • Interferon-alpha
  • Juvenile myleomonocytic leukemia (JMML)

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Successful treatment of JMML relapsed after unrelated allogeneic transplant with cytoreduction followed by DLI and interferon-alpha : Evidence for a graft-versus-leukemia effect in non-monosomy-7 JMML. / Pulsipher, M. A.; Adams, R. H.; Asch, J.; Petersen, F. B.

In: Bone Marrow Transplantation, Vol. 33, No. 1, 01.2004, p. 113-115.

Research output: Contribution to journalArticle

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