Successful treatment of a child with T/myeloid acute bilineal leukemia associated with TLX3/BCL11B fusion and 9q deletion

Jennifer L. Oliveira, Riten Kumar, Shakila P. Khan, Mark E. Law, Michele Erickson-Johnson, Andre M. Oliveira, Rhett P. Ketterling, Ahmet Dogan

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Acute bilineal leukemias are rare and are commonly associated with t(9;22) and MLL abnormalities. Herein, we report a pediatric case of bilineal T/myeloid acute leukemia associated with del (9q)(q13q22) and TLX3/BCL11B fusion due to the cryptic t(5;14)(q35;32). FISH studies confirmed the TLX3/BCL11B fusion in both the myeloid and lymphoid blasts, while the 9q deletion was restricted to the lymphoid component. Optimal therapy for such patients remains controversial and it is not clear if they should be treated with ALL or AML-based chemotherapeutic regimens. Our patient has been in extended remission following ALL-based chemotherapy and a matched unrelated cord blood transplant.

Original languageEnglish (US)
Pages (from-to)467-469
Number of pages3
JournalPediatric Blood and Cancer
Volume56
Issue number3
DOIs
StatePublished - Mar 1 2011

Keywords

  • Acute bilineal leukemia
  • Ambiguous
  • BCL11B
  • Biphenotypic
  • HOX11L2
  • MPAL
  • T(5 ;14), 9q
  • T-ALL
  • T/myeloid
  • TLX3

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Successful treatment of a child with T/myeloid acute bilineal leukemia associated with TLX3/BCL11B fusion and 9q deletion'. Together they form a unique fingerprint.

  • Cite this

    Oliveira, J. L., Kumar, R., Khan, S. P., Law, M. E., Erickson-Johnson, M., Oliveira, A. M., Ketterling, R. P., & Dogan, A. (2011). Successful treatment of a child with T/myeloid acute bilineal leukemia associated with TLX3/BCL11B fusion and 9q deletion. Pediatric Blood and Cancer, 56(3), 467-469. https://doi.org/10.1002/pbc.22850