Successful radiofrequency ablation of the cerebral cortex in pigs using the venous system: Possible implications for treating CNS disorders

Benhur D. Henz, Paul Andrew Friedman, Charles J Bruce, David Holmes, Yasuo Okumura, Susan B. Johnson, Douglas L Packer, Samuel J Asirvatham

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: When pharmacotherapy for epilepsy fails, surgical options, although efficacious, are highly invasive. We explored whether ablation of the cerebral cortex can be performed utilizing the cerebral venous system. Methods: Mapping and radiofrequency ablation was performed via the venous system in two pigs. Results: Eight targeted sites were successfully accessed and four targeted sites successfully ablated via the central cerebral venous network. Conclusion: Electrophysiological mapping and radiofrequency ablation of the cerebral cortex can be performed via the cerebral veins.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalEpilepsy Research
Volume80
Issue number2-3
DOIs
StatePublished - Aug 2008

Fingerprint

Cerebral Cortex
Swine
Cerebral Veins
Epilepsy
Drug Therapy

Keywords

  • Catheter ablation
  • Cerebralcortex
  • Epilepsy
  • Radiofrequency
  • Venous system

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

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abstract = "Background: When pharmacotherapy for epilepsy fails, surgical options, although efficacious, are highly invasive. We explored whether ablation of the cerebral cortex can be performed utilizing the cerebral venous system. Methods: Mapping and radiofrequency ablation was performed via the venous system in two pigs. Results: Eight targeted sites were successfully accessed and four targeted sites successfully ablated via the central cerebral venous network. Conclusion: Electrophysiological mapping and radiofrequency ablation of the cerebral cortex can be performed via the cerebral veins.",
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T2 - Possible implications for treating CNS disorders

AU - Henz, Benhur D.

AU - Friedman, Paul Andrew

AU - Bruce, Charles J

AU - Holmes, David

AU - Okumura, Yasuo

AU - Johnson, Susan B.

AU - Packer, Douglas L

AU - Asirvatham, Samuel J

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AB - Background: When pharmacotherapy for epilepsy fails, surgical options, although efficacious, are highly invasive. We explored whether ablation of the cerebral cortex can be performed utilizing the cerebral venous system. Methods: Mapping and radiofrequency ablation was performed via the venous system in two pigs. Results: Eight targeted sites were successfully accessed and four targeted sites successfully ablated via the central cerebral venous network. Conclusion: Electrophysiological mapping and radiofrequency ablation of the cerebral cortex can be performed via the cerebral veins.

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KW - Epilepsy

KW - Radiofrequency

KW - Venous system

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