Successful radiofrequency ablation of the cerebral cortex in pigs using the venous system: Possible implications for treating CNS disorders

Background: When pharmacotherapy for epilepsy fails, surgical options, although efficacious, are highly invasive. We explored whether ablation of the cerebral cortex can be performed utilizing the cerebral venous system. Methods: Mapping and radiofrequency ablation was performed via the venous system in two pigs. Results: Eight targeted sites were successfully accessed and four targeted sites successfully ablated via the central cerebral venous network. Conclusion: Electrophysiological mapping and radiofrequency ablation of the cerebral cortex can be performed via the cerebral veins.