Successful radiofrequency ablation of the cerebral cortex in pigs using the venous system: Possible implications for treating CNS disorders

Benhur D. Henz, Paul A. Friedman, Charles J. Bruce, David R. Holmes, Yasuo Okumura, Susan B. Johnson, Douglas L. Packer, Samuel J. Asirvatham

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: When pharmacotherapy for epilepsy fails, surgical options, although efficacious, are highly invasive. We explored whether ablation of the cerebral cortex can be performed utilizing the cerebral venous system. Methods: Mapping and radiofrequency ablation was performed via the venous system in two pigs. Results: Eight targeted sites were successfully accessed and four targeted sites successfully ablated via the central cerebral venous network. Conclusion: Electrophysiological mapping and radiofrequency ablation of the cerebral cortex can be performed via the cerebral veins.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalEpilepsy Research
Volume80
Issue number2-3
DOIs
StatePublished - Aug 1 2008

Keywords

  • Catheter ablation
  • Cerebralcortex
  • Epilepsy
  • Radiofrequency
  • Venous system

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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