Successful palliation of hypercalcemia secondary to metastatic parathyroid cancer: An unusual indication for hepatic resection

James J. Mezhir, Marcovalerio Melis, Ryan C. Headley, Rish Pai, Mitchell C. Posner, Edwin L. Kaplan

Research output: Contribution to journalArticle

8 Scopus citations


Primary carcinoma of the parathyroid gland is a rare disease. It is often diagnosed after recurrence of hyperparathyroidism following resection for presumed adenomatous disease. Local and distant recurrence is high and aggressive resection is advocated. Patients with parathyroid cancer are frequently plagued by severe hypercalcemia, which is often refractory to medical therapy. Herein we describe the case of a patient with metastatic parathyroid cancer localized to the liver. The patient was treated with a palliative hepatic resection for the management of persistent and refractory hypercalcemia. Intraoperative parathyroid hormone levels were utilized as an adjunct to determine successful metastatectomy. Our case highlights the importance of an aggressive approach to patients with metastatic parathyroid cancer, as well as the utility of intraoperative parathyroid hormone levels to confirm successful extirpation of disease.

Original languageEnglish (US)
Pages (from-to)410-413
Number of pages4
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Issue number4
StatePublished - Jul 1 2007
Externally publishedYes



  • Hepatic metastasis
  • Hepatic resection
  • Hyper calcemia
  • Intraoperative parathyroid monitoring
  • Parathyroid cancer

ASJC Scopus subject areas

  • Surgery

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