Abstract
Background and objectives: We aimed to determine outcomes with transplanting kidneys from deceased donors with severe acute kidney injury requiring acute renal replacement therapy (RRT). Materials and methods: A total of 172 recipients received a kidney from donors with acute kidney injury stage 3 (AKIN3) requiring RRT. We compared the study group to 528 recipients who received a kidney from donors with AKIN stage 3 not on RRT and 463 recipients who received < 85% Kidney Donor Profile Index (KDPI) AKIN stage 0 kidney. Results: The study group donors were younger compared to the 2 control groups. Despite higher DGF in the study group, the length of hospital stay and acute rejection were similar. Death censored graft survival (96% AKIN3-RRT vs. 97%AKIN3 no RRT vs. 96% KDPI < 85% AKIN0, P = 0.26) and patient survival with functioning graft at 1 year (95% across all groups, P = 0.402) were similar. The estimated glomerular filtration rate were similar across the 3 groups after first month. Interstitial fibrosis and tubular atrophy score ≥ 2 on protocol biopsy at time 0, 4 and 12 months were similar. Primary nonfunction was rare and associated with high KDPI. Conclusions: Transplanting selected kidneys from deceased donors with AKIN3 requiring RRT is safe and has good outcomes.
Original language | English (US) |
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Article number | e14465 |
Journal | Clinical Transplantation |
Volume | 35 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2021 |
Keywords
- acute kidney injury
- deceased donor
- graft survival
- kidney transplant
- organ procurement
- renal replacement therapy
ASJC Scopus subject areas
- Transplantation