Successful liver transplantation in a patient with severe haemophilia A and a high-titre factor VIII inhibitor

A. A. Ashrani, M. T. Reding, A. Shet, J. Osip, A. Humar, J. R. Lake, Nigel S. Key

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

We present the case of a 61-year-old man with severe haemophilia A and a high-titre factor VIII inhibitor who underwent successful orthotopic liver transplantation (OLT) for hepatocellular carcinoma. Postoperatively, a modest early anamnestic response to FVIII was followed by immunological tolerance to FVIII. This case illustrates the technical feasibility of OLT in some patients with high-titre inhibitors to FVIII, and suggests that immune tolerance may be induced by endogenously produced FVIII from the transplanted organ.

Original languageEnglish (US)
Pages (from-to)735-737
Number of pages3
JournalHaemophilia
Volume10
Issue number6
DOIs
StatePublished - Nov 1 2004

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)

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