Successful establishment of a left ventricular assist device program in an emerging country: One year experience

Emilija Nestorovic, Jan D. Schmitto, Sudhir S. Kushwaha, Svetozar Putnik, Dusko Terzic, Natasa Milic, Aleksandar Mikic, Dejan Markovic, Danijela Trifunovic, Arsen Ristic, Miljko Ristic

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: The primary goal of this study was to evaluate the outcomes of patients with end-stage heart failure (HF) who underwent continuous flow left ventricular assist device (CF-LVAD) in a developing country and to compare to those reported by more developed countries. The secondary goal was on determining factors that may be connected to improved survival. Methods: We prospectively analyzed 47 consecutive patients who underwent CF-LVAD at our institution. After one year the survival and adverse event profiles of patients were evaluated. At 3, 6 and 12 months, the cardiac, renal and liver function outcomes were assessed. Results: The 30-day, 6-month and 1-year survival rates were 89%, 85% and 80%, respectively. A significant improvement in dimensions and ejection fraction of left ventricle, BNP, functional capacity, blood urea nitrogen (BUN) and total bilirubin (P < 0.05 for all) were noticed 3 months post-CF-LVAD implantation, and patients were stable throughout the entire first year follow up. In the group of patients with baseline renal dysfunction (RD) there were significant improvements of renal function (P=0.004), with no changes on follow up. 57% of patients exhibited some kind of adverse event, commonly in the form of bleeding. In multivariate Cox regression analysis renal failure was found to be as an independent risk factor for the overall survival (HR =13.1, P < 0.001). Conclusions: In conclusion, our data extends previous findings from centers of developed countries, that CF-LVAD is an adequate treatment option for patients suffering from end-stage HF, and encourages expansion of CF-LVAD implantation in developing countries with nascent HT program.

Original languageEnglish (US)
Pages (from-to)S1743-S1750
JournalJournal of Thoracic Disease
Volume10
DOIs
StatePublished - Jun 1 2018

Keywords

  • End-stage heart failure
  • Left ventricular assist device (LVAD)
  • Less developed country
  • Outcomes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Nestorovic, E., Schmitto, J. D., Kushwaha, S. S., Putnik, S., Terzic, D., Milic, N., Mikic, A., Markovic, D., Trifunovic, D., Ristic, A., & Ristic, M. (2018). Successful establishment of a left ventricular assist device program in an emerging country: One year experience. Journal of Thoracic Disease, 10, S1743-S1750. https://doi.org/10.21037/jtd.2018.04.147