Successful encorafenib desensitization in a patient with recurrent metastatic melanoma

Grace D. Cullen; Heidi D. Finnes; Svetomir N. Markovic; Gerald W. Volcheck

doi:10.1097/CMR.0000000000000757

Successful encorafenib desensitization in a patient with recurrent metastatic melanoma

Grace D. Cullen, Heidi D. Finnes, Svetomir N. Markovic, Gerald W. Volcheck

Hematology

Research output: Contribution to journal › Article › peer-review

Abstract

Type I hypersensitivity reactions (HSR) to dabrafenib are rare but have been previously described. We present a case where a 72-year-old woman with recurrent, metastatic BRAF-mutated melanoma developed a type I HSR to dabrafenib. We, therefore, developed a desensitization protocol with encorafenib, a similar class agent, to allow the patient to continue with treatment. Patients with a history of HSR to dabrafenib may be considered for encorafenib desensitization when other therapeutic options are limited.

Original language	English (US)
Pages (from-to)	402-404
Number of pages	3
Journal	Melanoma research
Volume	31
Issue number	4
DOIs	https://doi.org/10.1097/CMR.0000000000000757
State	Published - Aug 1 2021

Keywords

B-raf (BRAF)
dabrafenib
hypersensitivity reaction

ASJC Scopus subject areas

Dermatology
Oncology
Cancer Research

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10.1097/CMR.0000000000000757

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title = "Successful encorafenib desensitization in a patient with recurrent metastatic melanoma",

abstract = "Type I hypersensitivity reactions (HSR) to dabrafenib are rare but have been previously described. We present a case where a 72-year-old woman with recurrent, metastatic BRAF-mutated melanoma developed a type I HSR to dabrafenib. We, therefore, developed a desensitization protocol with encorafenib, a similar class agent, to allow the patient to continue with treatment. Patients with a history of HSR to dabrafenib may be considered for encorafenib desensitization when other therapeutic options are limited.",

keywords = "B-raf (BRAF), dabrafenib, hypersensitivity reaction",

author = "Cullen, {Grace D.} and Finnes, {Heidi D.} and Markovic, {Svetomir N.} and Volcheck, {Gerald W.}",

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doi = "10.1097/CMR.0000000000000757",

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T1 - Successful encorafenib desensitization in a patient with recurrent metastatic melanoma

AU - Cullen, Grace D.

AU - Finnes, Heidi D.

AU - Markovic, Svetomir N.

AU - Volcheck, Gerald W.

PY - 2021/8/1

Y1 - 2021/8/1

N2 - Type I hypersensitivity reactions (HSR) to dabrafenib are rare but have been previously described. We present a case where a 72-year-old woman with recurrent, metastatic BRAF-mutated melanoma developed a type I HSR to dabrafenib. We, therefore, developed a desensitization protocol with encorafenib, a similar class agent, to allow the patient to continue with treatment. Patients with a history of HSR to dabrafenib may be considered for encorafenib desensitization when other therapeutic options are limited.

AB - Type I hypersensitivity reactions (HSR) to dabrafenib are rare but have been previously described. We present a case where a 72-year-old woman with recurrent, metastatic BRAF-mutated melanoma developed a type I HSR to dabrafenib. We, therefore, developed a desensitization protocol with encorafenib, a similar class agent, to allow the patient to continue with treatment. Patients with a history of HSR to dabrafenib may be considered for encorafenib desensitization when other therapeutic options are limited.

KW - B-raf (BRAF)

KW - dabrafenib

KW - hypersensitivity reaction

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ER -

Successful encorafenib desensitization in a patient with recurrent metastatic melanoma

Abstract

Keywords

ASJC Scopus subject areas

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