Success of short-term, higher-dose imatinib mesylate to induce clinical response in FIP1L1-PDGFRα-negative hypereosinophilic syndrome

Joseph H. Butterfield

Research output: Contribution to journalArticle

35 Scopus citations


Presence of the oncogenic mutation FIP1L1-PDGFRα in hypereosinophilic patients is predictive of hematologic response to imatinib mesylate. However, most patients with hypereosinophilic syndrome (HES) do not have this mutation and have not responded to imatinib doses traditionally successful in patients who test positive for FIP1L1-PDGFRα. A patient with FIP1L1-PDGFRα-negative HES who had intolerance of interferon α-2b and hydroxyurea was treated with escalating doses of imatinib. At 800 mg of imatinib daily, eosinophilia was controlled, allowing prednisone tapering and control of clinical and laboratory-detected abnormalities. HES patients who test negative for FIP1L1-PDGFRα may benefit from a trial of higher-dose imatinib.

Original languageEnglish (US)
Pages (from-to)1127-1129
Number of pages3
JournalLeukemia Research
Issue number8
StatePublished - Aug 1 2009



  • Hematologic diseases
  • Human FIP1L1-PDGFRα fusion protein
  • Hypereosinophilic syndrome
  • Imatinib mesylate
  • Interferon-α
  • Mutation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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