Three patients, each with a nonspecific clinical history and raised serum alkaline phosphatase levels, were referred for investigation of hepatobiliary disorders. Isoenzyme analysis showed both hepatic and bony isoenzymes to be elevated, and eventually hyperthyroidism was diagnosed in each patient. Hyperthyroidism can be difficult to recognize clinically, and isolated elevation of serum alkaline phosphatase levels may be a useful clue.
- Alkaline phosphatase
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