Subtle BBB alterations in brain edema associated with acute liver failure

Research output: Contribution to journalLetter

2 Scopus citations

Abstract

Vasogenic mechanism of brain edema in acute liver failure (ALF) remains poorly understood. Recent work demonstrates that matrix metalloproteinase-9 (MMP-9) contributes to the development of brain edema in experimental ALF (J Hepatol 44:1105, 2006). Importantly, MMP-9 blockage with specific monoclonal antibodies and/or synthetic inhibitor, the edema is attenuated. Specifically, utrastructural evaluations demonstrate intact blood-brain barrier and its tight junction. These results suggest that subtle alterations in BBB are likely to involve in the brain edema associated with ALF.

Original languageEnglish (US)
Pages (from-to)203-204
Number of pages2
JournalNeurochemistry International
Volume56
Issue number2
DOIs
StatePublished - Jan 1 2010

Keywords

  • Acute liver failure
  • Blood-brain barrier
  • Brain edema

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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