Subthalamic nucleus deep brain stimulation induces motor network BOLD activation

Use of a high precision MRI guided stereotactic system for nonhuman primates

Hoon Ki Min, Erika K. Ross, Kendall H Lee, Kendall Dennis, Seong Rok Han, Ju Ho Jeong, Michael P. Marsh, Bryan Striemer, Joel P. Felmlee, Jose Lujan, Steve Goerss, Penelope S. Duffy, Charles D. Blaha, Su-Youne Chang, Kevin E. Bennet

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background Functional magnetic resonance imaging (fMRI) is a powerful method for identifying in vivo network activation evoked by deep brain stimulation (DBS). Objective Identify the global neural circuitry effect of subthalamic nucleus (STN) DBS in nonhuman primates (NHP). Method An in-house developed MR image-guided stereotactic targeting system delivered a mini-DBS stimulating electrode, and blood oxygenation level-dependent (BOLD) activation during STN DBS in healthy NHP was measured by combining fMRI with a normalized functional activation map and general linear modeling. Results STN DBS significantly increased BOLD activation in the sensorimotor cortex, supplementary motor area, caudate nucleus, pedunculopontine nucleus, cingulate, insular cortex, and cerebellum (FDR < 0.001). Conclusion Our results demonstrate that STN DBS evokes neural network grouping within the motor network and the basal ganglia. Taken together, these data highlight the importance and specificity of neural circuitry activation patterns and functional connectivity.

Original languageEnglish (US)
Pages (from-to)603-607
Number of pages5
JournalBrain Stimulation
Volume7
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Subthalamic Nucleus
Deep Brain Stimulation
Primates
Magnetic Resonance Imaging
Caudate Nucleus
Gyrus Cinguli
Motor Cortex
Basal Ganglia
Cerebral Cortex
Cerebellum
Electrodes

Keywords

  • Deep brain stimulation
  • Functional magnetic resonance imaging
  • Motor cortex
  • Nonhuman primate
  • Pedunculopontine nucleus
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Biophysics

Cite this

Subthalamic nucleus deep brain stimulation induces motor network BOLD activation : Use of a high precision MRI guided stereotactic system for nonhuman primates. / Min, Hoon Ki; Ross, Erika K.; Lee, Kendall H; Dennis, Kendall; Han, Seong Rok; Jeong, Ju Ho; Marsh, Michael P.; Striemer, Bryan; Felmlee, Joel P.; Lujan, Jose; Goerss, Steve; Duffy, Penelope S.; Blaha, Charles D.; Chang, Su-Youne; Bennet, Kevin E.

In: Brain Stimulation, Vol. 7, No. 4, 2014, p. 603-607.

Research output: Contribution to journalArticle

Min, HK, Ross, EK, Lee, KH, Dennis, K, Han, SR, Jeong, JH, Marsh, MP, Striemer, B, Felmlee, JP, Lujan, J, Goerss, S, Duffy, PS, Blaha, CD, Chang, S-Y & Bennet, KE 2014, 'Subthalamic nucleus deep brain stimulation induces motor network BOLD activation: Use of a high precision MRI guided stereotactic system for nonhuman primates', Brain Stimulation, vol. 7, no. 4, pp. 603-607. https://doi.org/10.1016/j.brs.2014.04.007
Min, Hoon Ki ; Ross, Erika K. ; Lee, Kendall H ; Dennis, Kendall ; Han, Seong Rok ; Jeong, Ju Ho ; Marsh, Michael P. ; Striemer, Bryan ; Felmlee, Joel P. ; Lujan, Jose ; Goerss, Steve ; Duffy, Penelope S. ; Blaha, Charles D. ; Chang, Su-Youne ; Bennet, Kevin E. / Subthalamic nucleus deep brain stimulation induces motor network BOLD activation : Use of a high precision MRI guided stereotactic system for nonhuman primates. In: Brain Stimulation. 2014 ; Vol. 7, No. 4. pp. 603-607.
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