TY - JOUR
T1 - Substance p for evaluation of coronary endothelial function after cardiac transplantation
AU - Kushwaha, Sudhir S.
AU - Crossman, David C.
AU - Bustami, Mahmud
AU - Davies, Graham J.
AU - Mitchell, Andrew G.
AU - Maseri, Attilio
AU - Yacoub, Magdi H.
PY - 1991/6
Y1 - 1991/6
N2 - The endothelium-dependent vasodilator substance P dilates normal and diseased coronary vessels in humans in vivo and produces a maximal response similar to that seen with intracoronary isosorbide dinitrate. Twelve cardiac transplant recipients underwent intracoronary infusion of substance P after routine annual investigations. All patients were well, with no evidence of rejection and with angiographically normal coronary arteries. Substance P was infused at 2 ml/min for 2 min into the coronary artery, starting at a dose of 1.4 pmol/min and increasing by doubling increments, and followed by isosorbide dinitrate (1 mg/min) infused over 2 min. Coronary artery diameter was measured in 23 vessel segments from 12 transplant recipients. The following doses were infused: saline solution (1 ml/min), substance P (0.7 [three patients], 1.4, 2.8, 5.6, 11.2, 22.4 pmol/ min) and isosorbide dinitrate (1 mg/min). The mean percent increase in diameter (± SEM) in response to increasing doses of substance P was as follows: 0. 6.5 ± 2.9%, 10.9 ± 2.9%, 12.1 ±2.9%, 16.5 ± 2.6%, 19.2 ± 3.1% and 25.8 ± 2.2%, respectively. Half maximal dilation was produced with 1.4 to 2.8 pmol/min of substance P; the maximal response (mean percent diameter change) was 22 ± 2.5%. This was not significantly different from that achieved with isosorbide dinitrate. It is concluded that coronary endothelial function as assessed by response to substance P is preserved in cardiac transplant recipients with angiographically normal coronary arteries. Substance P may be a suitable agent for testing endothelial function in these patients.
AB - The endothelium-dependent vasodilator substance P dilates normal and diseased coronary vessels in humans in vivo and produces a maximal response similar to that seen with intracoronary isosorbide dinitrate. Twelve cardiac transplant recipients underwent intracoronary infusion of substance P after routine annual investigations. All patients were well, with no evidence of rejection and with angiographically normal coronary arteries. Substance P was infused at 2 ml/min for 2 min into the coronary artery, starting at a dose of 1.4 pmol/min and increasing by doubling increments, and followed by isosorbide dinitrate (1 mg/min) infused over 2 min. Coronary artery diameter was measured in 23 vessel segments from 12 transplant recipients. The following doses were infused: saline solution (1 ml/min), substance P (0.7 [three patients], 1.4, 2.8, 5.6, 11.2, 22.4 pmol/ min) and isosorbide dinitrate (1 mg/min). The mean percent increase in diameter (± SEM) in response to increasing doses of substance P was as follows: 0. 6.5 ± 2.9%, 10.9 ± 2.9%, 12.1 ±2.9%, 16.5 ± 2.6%, 19.2 ± 3.1% and 25.8 ± 2.2%, respectively. Half maximal dilation was produced with 1.4 to 2.8 pmol/min of substance P; the maximal response (mean percent diameter change) was 22 ± 2.5%. This was not significantly different from that achieved with isosorbide dinitrate. It is concluded that coronary endothelial function as assessed by response to substance P is preserved in cardiac transplant recipients with angiographically normal coronary arteries. Substance P may be a suitable agent for testing endothelial function in these patients.
UR - http://www.scopus.com/inward/record.url?scp=0025734963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025734963&partnerID=8YFLogxK
U2 - 10.1016/0735-1097(91)90644-O
DO - 10.1016/0735-1097(91)90644-O
M3 - Article
C2 - 1709653
AN - SCOPUS:0025734963
SN - 0735-1097
VL - 17
SP - 1537
EP - 1544
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 7
ER -