Substance p for evaluation of coronary endothelial function after cardiac transplantation

Sudhir S. Kushwaha, David C. Crossman, Mahmud Bustami, Graham J. Davies, Andrew G. Mitchell, Attilio Maseri, Magdi H. Yacoub

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29 Scopus citations

Abstract

The endothelium-dependent vasodilator substance P dilates normal and diseased coronary vessels in humans in vivo and produces a maximal response similar to that seen with intracoronary isosorbide dinitrate. Twelve cardiac transplant recipients underwent intracoronary infusion of substance P after routine annual investigations. All patients were well, with no evidence of rejection and with angiographically normal coronary arteries. Substance P was infused at 2 ml/min for 2 min into the coronary artery, starting at a dose of 1.4 pmol/min and increasing by doubling increments, and followed by isosorbide dinitrate (1 mg/min) infused over 2 min. Coronary artery diameter was measured in 23 vessel segments from 12 transplant recipients. The following doses were infused: saline solution (1 ml/min), substance P (0.7 [three patients], 1.4, 2.8, 5.6, 11.2, 22.4 pmol/ min) and isosorbide dinitrate (1 mg/min). The mean percent increase in diameter (± SEM) in response to increasing doses of substance P was as follows: 0. 6.5 ± 2.9%, 10.9 ± 2.9%, 12.1 ±2.9%, 16.5 ± 2.6%, 19.2 ± 3.1% and 25.8 ± 2.2%, respectively. Half maximal dilation was produced with 1.4 to 2.8 pmol/min of substance P; the maximal response (mean percent diameter change) was 22 ± 2.5%. This was not significantly different from that achieved with isosorbide dinitrate. It is concluded that coronary endothelial function as assessed by response to substance P is preserved in cardiac transplant recipients with angiographically normal coronary arteries. Substance P may be a suitable agent for testing endothelial function in these patients.

Original languageEnglish (US)
Pages (from-to)1537-1544
Number of pages8
JournalJournal of the American College of Cardiology
Volume17
Issue number7
DOIs
StatePublished - Jun 1991

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Kushwaha, S. S., Crossman, D. C., Bustami, M., Davies, G. J., Mitchell, A. G., Maseri, A., & Yacoub, M. H. (1991). Substance p for evaluation of coronary endothelial function after cardiac transplantation. Journal of the American College of Cardiology, 17(7), 1537-1544. https://doi.org/10.1016/0735-1097(91)90644-O