Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy

Stuart J. McCarter; John C. Feemster; Grace M. Tabatabai; David J. Sandness; Paul C. Timm; Allison R. McCarter; Heather N. Talley; Mithri R. Junna; Rodolfo Savica; Wolfgang Singer; Elizabeth A. Coon; Eduardo E. Benarroch; Keith A. Josephs; Bradley F. Boeve; Michael H. Silber; Erik K. St. Louis

doi:10.1002/ana.25622

Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy

Stuart J. McCarter, John C. Feemster, Grace M. Tabatabai, David J. Sandness, Paul C. Timm, Allison R. McCarter, Heather N. Talley, Mithri R. Junna, Rodolfo Savica, Wolfgang Singer, Elizabeth A. Coon, Eduardo E. Benarroch, Keith A. Josephs, Bradley F. Boeve, Michael H. Silber, Erik K. St. Louis

Neurology

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4 Scopus citations

Abstract

Accurate antemortem diagnosis of parkinsonism is primarily based on clinical evaluation with limited biomarkers. We evaluated the diagnostic utility of quantitative rapid eye movement (REM) sleep without atonia analysis in the submentalis and anterior tibialis muscles in parkinsonian patients (53 synucleinopathy, 24 tauopathy). Receiver operating characteristic curves determined REM sleep without atonia cutoffs distinguishing synucleinopathies from tauopathies. Elevated submentalis muscle activity was highly sensitive (70–77%) and specific (95–100%) in distinguishing synucleinopathy from tauopathy. In contrast, anterior tibialis synucleinopathy discrimination was poor. Our results suggest that elevated submentalis REM sleep without atonia appears to be a potentially useful biomarker for presumed synucleinopathy etiologies in parkinsonism. ANN NEUROL 2019;86:969–974.

Original language	English (US)
Pages (from-to)	969-974
Number of pages	6
Journal	Annals of neurology
Volume	86
Issue number	6
DOIs	https://doi.org/10.1002/ana.25622
State	Published - Dec 1 2019

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/ana.25622

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McCarter, S. J., Feemster, J. C., Tabatabai, G. M., Sandness, D. J., Timm, P. C., McCarter, A. R., Talley, H. N., Junna, M. R., Savica, R., Singer, W., Coon, E. A., Benarroch, E. E., Josephs, K. A., Boeve, B. F., Silber, M. H., & St. Louis, E. K. (2019). Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy. Annals of neurology, 86(6), 969-974. https://doi.org/10.1002/ana.25622

McCarter, SJ, Feemster, JC, Tabatabai, GM, Sandness, DJ, Timm, PC, McCarter, AR, Talley, HN, Junna, MR, Savica, R , Singer, W , Coon, EA, Benarroch, EE, Josephs, KA , Boeve, BF, Silber, MH & St. Louis, EK 2019, 'Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy', Annals of neurology, vol. 86, no. 6, pp. 969-974. https://doi.org/10.1002/ana.25622

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abstract = "Accurate antemortem diagnosis of parkinsonism is primarily based on clinical evaluation with limited biomarkers. We evaluated the diagnostic utility of quantitative rapid eye movement (REM) sleep without atonia analysis in the submentalis and anterior tibialis muscles in parkinsonian patients (53 synucleinopathy, 24 tauopathy). Receiver operating characteristic curves determined REM sleep without atonia cutoffs distinguishing synucleinopathies from tauopathies. Elevated submentalis muscle activity was highly sensitive (70–77%) and specific (95–100%) in distinguishing synucleinopathy from tauopathy. In contrast, anterior tibialis synucleinopathy discrimination was poor. Our results suggest that elevated submentalis REM sleep without atonia appears to be a potentially useful biomarker for presumed synucleinopathy etiologies in parkinsonism. ANN NEUROL 2019;86:969–974.",

author = "McCarter, {Stuart J.} and Feemster, {John C.} and Tabatabai, {Grace M.} and Sandness, {David J.} and Timm, {Paul C.} and McCarter, {Allison R.} and Talley, {Heather N.} and Junna, {Mithri R.} and Rodolfo Savica and Wolfgang Singer and Coon, {Elizabeth A.} and Benarroch, {Eduardo E.} and Josephs, {Keith A.} and Boeve, {Bradley F.} and Silber, {Michael H.} and {St. Louis}, {Erik K.}",

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AU - McCarter, Stuart J.

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AU - Tabatabai, Grace M.

AU - Sandness, David J.

AU - Timm, Paul C.

AU - McCarter, Allison R.

AU - Talley, Heather N.

AU - Junna, Mithri R.

AU - Savica, Rodolfo

AU - Singer, Wolfgang

AU - Coon, Elizabeth A.

AU - Benarroch, Eduardo E.

AU - Josephs, Keith A.

AU - Boeve, Bradley F.

AU - Silber, Michael H.

AU - St. Louis, Erik K.

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AB - Accurate antemortem diagnosis of parkinsonism is primarily based on clinical evaluation with limited biomarkers. We evaluated the diagnostic utility of quantitative rapid eye movement (REM) sleep without atonia analysis in the submentalis and anterior tibialis muscles in parkinsonian patients (53 synucleinopathy, 24 tauopathy). Receiver operating characteristic curves determined REM sleep without atonia cutoffs distinguishing synucleinopathies from tauopathies. Elevated submentalis muscle activity was highly sensitive (70–77%) and specific (95–100%) in distinguishing synucleinopathy from tauopathy. In contrast, anterior tibialis synucleinopathy discrimination was poor. Our results suggest that elevated submentalis REM sleep without atonia appears to be a potentially useful biomarker for presumed synucleinopathy etiologies in parkinsonism. ANN NEUROL 2019;86:969–974.

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Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy

Abstract

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