Subjective cognitive impairment et maladie d'Alzheimer: Étude d'une cohorte de 51 sujets suivis sur deux ans

Translated title of the contribution: Subjective cognitive impairment and Alzheimer's disease: A two year follow up of 51 subjects during two years

Nathalie Sambuchi, Isabelle Muraccioli, BÉatrice Alescio-Lautier, VÉronique Paban, Roland Sambuc, Élisabeth Jouve, Yonas Endale Geda, Ronald Karl Petersen, Bernard François Michel

Research output: Contribution to journalArticle

2 Scopus citations


Subjective cognitive impairment (SCI) is defined by a state of subjective complaint, without objective cognitive deterioration. Amnestic mild cognitive impairment (A-MCI), which characterizes a syndrome between normal cognitive aging and early Alzheimer's disease (E-AD), is preceded by A-MCI from many years. SCI expresses a metacognitive impairment. A cohort of 51 subjects [7 normal controls (NC), 28 SCI, 12 A-MCI and 5 E-AD] was followed up during 24 months, with a neuropsychological evaluation each 6 months during 1 year (V1, V2, V3), then 1 year later (V4). Among the 28 SCI, 6 converted to A-MCI at V4 (21.42%), 1 to A-MCI-A at V3, then to E-AD at V4. These results suggest a continuum from SCI to A-MCI, and E-AD. Progressive SCI differed from non-progressive SCI on verbal episodic memory and executive functions tests at the initial examination. MRI showed anterior cingular atrophy in all SCI patients but hippocampal atrophy was only observed in 20 patients. Our results suggest that metacognition impairment is the expression of a dysfunction in the anterior pre-frontal cortex, in correlation with a syndrome of hyper-attention.

Original languageFrench
Pages (from-to)462-471
Number of pages10
JournalGeriatrie et Psychologie Neuropsychiatrie du Vieillissement
Issue number4
StatePublished - Dec 2015



  • Alzheimer's disease
  • Amnestic mild cognitive impairment
  • Anterior cingular cortex
  • Memory complaint
  • Metacognition
  • Subjective cognitive impairment

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Biological Psychiatry

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