Subependymoma involving multiple spinal cord levels: A clinicopathological case series with chromosomal microarray analysis

Anthony L. Mikula, Michael A. Paolini, William R. Sukov, Michelle J. Clarke, Aditya Raghunathan

Research output: Contribution to journalArticle

Abstract

Subependymomas of the spinal cord are rare, do not often involve multiple levels, and very rarely recur. Here, we present a series of spinal cord subependymomas with a detailed description of the clinical, radiological and pathological features, and characterization by chromosomal microarray analysis. Briefly, the four patients included two men and two women, between the ages of 22 and 48 years. The most common presenting symptoms were neck and arm pain with upper extremity weakness. By imaging, the tumors were found to involve multiple spinal levels, including cervical/ cervico-thoracic (three patients) and thoracic (one patient), were all eccentric, and had minimal to no post-contrast enhancement. Two patients underwent gross total resection, one had a sub-total resection, and one underwent biopsy alone with a decompressive laminectomy. Follow up ranged from 6 months to 22 years. One patient (case 4) had recurrence 15 years following gross total resection and chromosomal microarray analysis revealed deletions on the long arm of chromosome 6. Our limited series suggests that spinal cord subependymomas can rarely recur, even following gross total resection, suggesting a possible role for long-term surveillance for these rare tumors.

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalNeuropathology
Volume39
Issue number2
DOIs
StatePublished - Apr 1 2019

Fingerprint

Subependymal Glioma
Microarray Analysis
Spinal Cord
Thorax
Chromosomes, Human, Pair 6
Laminectomy
Neck Pain
Upper Extremity
Neoplasms
Arm
Biopsy
Recurrence

Keywords

  • chromosomal microarray
  • intramedullary tumor
  • long term recurrence
  • spinal cord
  • subependymoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Subependymoma involving multiple spinal cord levels : A clinicopathological case series with chromosomal microarray analysis. / Mikula, Anthony L.; Paolini, Michael A.; Sukov, William R.; Clarke, Michelle J.; Raghunathan, Aditya.

In: Neuropathology, Vol. 39, No. 2, 01.04.2019, p. 97-105.

Research output: Contribution to journalArticle

Mikula, Anthony L. ; Paolini, Michael A. ; Sukov, William R. ; Clarke, Michelle J. ; Raghunathan, Aditya. / Subependymoma involving multiple spinal cord levels : A clinicopathological case series with chromosomal microarray analysis. In: Neuropathology. 2019 ; Vol. 39, No. 2. pp. 97-105.
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