Subcutaneous botulinum toxin type A inhibits regional sweating: An individual observation

W. P. Cheshire

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Botulinum toxin inhibits neuromuscular transmission by blocking the exocytosis of acetylcholine. It was tested for a similar effect on cholinergic postganglionic sympathetic neurones at the sudomotor junction. Subcutaneous injections of 0.1 and 1.0 units of type A botulinum toxin into the forearm of a healthy subject abolished local thermoregulatory sweating in cutaneous regions spanning 1.0 and 1.5 cm for nearly 1 year without producing weakness. Botulinum toxin, therefore appears to have potent anhidrotic activity.

Original languageEnglish (US)
Pages (from-to)123-124
Number of pages2
JournalClinical Autonomic Research
Volume6
Issue number2
DOIs
StatePublished - Jun 27 1996

Keywords

  • Botulinum toxin
  • Sweating
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology

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