Subcutaneous botulinum toxin type A inhibits regional sweating: An individual observation

W. P. Cheshire

doi:10.1007/BF02291235

Subcutaneous botulinum toxin type A inhibits regional sweating: An individual observation

W. P. Cheshire

Neurology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Botulinum toxin inhibits neuromuscular transmission by blocking the exocytosis of acetylcholine. It was tested for a similar effect on cholinergic postganglionic sympathetic neurones at the sudomotor junction. Subcutaneous injections of 0.1 and 1.0 units of type A botulinum toxin into the forearm of a healthy subject abolished local thermoregulatory sweating in cutaneous regions spanning 1.0 and 1.5 cm for nearly 1 year without producing weakness. Botulinum toxin, therefore appears to have potent anhidrotic activity.

Original language	English (US)
Pages (from-to)	123-124
Number of pages	2
Journal	Clinical Autonomic Research
Volume	6
Issue number	2
DOIs	https://doi.org/10.1007/BF02291235
State	Published - 1996

Keywords

Botulinum toxin
Sweating
Sympathetic nervous system

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Clinical Neurology

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10.1007/BF02291235

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abstract = "Botulinum toxin inhibits neuromuscular transmission by blocking the exocytosis of acetylcholine. It was tested for a similar effect on cholinergic postganglionic sympathetic neurones at the sudomotor junction. Subcutaneous injections of 0.1 and 1.0 units of type A botulinum toxin into the forearm of a healthy subject abolished local thermoregulatory sweating in cutaneous regions spanning 1.0 and 1.5 cm for nearly 1 year without producing weakness. Botulinum toxin, therefore appears to have potent anhidrotic activity.",

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AB - Botulinum toxin inhibits neuromuscular transmission by blocking the exocytosis of acetylcholine. It was tested for a similar effect on cholinergic postganglionic sympathetic neurones at the sudomotor junction. Subcutaneous injections of 0.1 and 1.0 units of type A botulinum toxin into the forearm of a healthy subject abolished local thermoregulatory sweating in cutaneous regions spanning 1.0 and 1.5 cm for nearly 1 year without producing weakness. Botulinum toxin, therefore appears to have potent anhidrotic activity.

KW - Botulinum toxin

KW - Sweating

KW - Sympathetic nervous system

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Subcutaneous botulinum toxin type A inhibits regional sweating: An individual observation

Abstract

Keywords

ASJC Scopus subject areas

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