Subcellular distribution of aromatase in human placenta and ovary

E Aubrey Thompson, P. K. Siiteri

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aromatization of androstenedione in human ovarian microsomes is inhibited by an antibody to porcine hepatic microsomal NADPH-cytochrome c reductase. Likewise, the antibody inhibits aromatization in mitochondria isolated from human ovaries and placentae. A given quantity of the antibody produces the same percent inhibition of aromatization in microsomes and mitochondria of both ovaries and placentae. These data, in addition to the low specific activity observed for the mitochondrial aromatase, indicate that aromatization in mitochondria probably results from microsomal contamination.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalHormone Research
Volume11
Issue number4
StatePublished - 1979
Externally publishedYes

Fingerprint

Aromatase
Placenta
Ovary
Mitochondria
Microsomes
Antibodies
NADPH-Ferrihemoprotein Reductase
Androstenedione
Swine
Liver

ASJC Scopus subject areas

  • Endocrinology

Cite this

Subcellular distribution of aromatase in human placenta and ovary. / Thompson, E Aubrey; Siiteri, P. K.

In: Hormone Research, Vol. 11, No. 4, 1979, p. 179-185.

Research output: Contribution to journalArticle

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