TY - JOUR
T1 - Studying Stroke Thrombus Composition After Thrombectomy
T2 - What Can We Learn?
AU - Staessens, Senna
AU - François, Olivier
AU - Brinjikji, Waleed
AU - Doyle, Karen M.
AU - Vanacker, Peter
AU - Andersson, Tommy
AU - De Meyer, Simon F.
N1 - Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - The composition of ischemic stroke thrombi has gained an increasing amount of interest in recent years. The implementation of endovascular procedures in standard stroke care has granted researchers the unique opportunity to examine patient thrombus material. Increasing evidence indicates that stroke thrombi are complex and heterogenous, consisting of various biochemical (eg, fibrin, von Willebrand Factor, and neutrophil extracellular traps) and cellular (eg, red blood cells, platelets, leukocytes, and bacteria) components. This complex composition may explain therapeutic limitations and also offer novel insights in several aspects of stroke management. Better understanding of thrombus characteristics could, therefore, potentially lead to improvements in the management of patients with stroke. In this review, we provide a comprehensive overview of the lessons learned by examining stroke thrombus composition after endovascular thrombectomy and its potential relevance for thrombectomy success rates, thrombolysis, clinical outcomes, stroke etiology, and radiological imaging.
AB - The composition of ischemic stroke thrombi has gained an increasing amount of interest in recent years. The implementation of endovascular procedures in standard stroke care has granted researchers the unique opportunity to examine patient thrombus material. Increasing evidence indicates that stroke thrombi are complex and heterogenous, consisting of various biochemical (eg, fibrin, von Willebrand Factor, and neutrophil extracellular traps) and cellular (eg, red blood cells, platelets, leukocytes, and bacteria) components. This complex composition may explain therapeutic limitations and also offer novel insights in several aspects of stroke management. Better understanding of thrombus characteristics could, therefore, potentially lead to improvements in the management of patients with stroke. In this review, we provide a comprehensive overview of the lessons learned by examining stroke thrombus composition after endovascular thrombectomy and its potential relevance for thrombectomy success rates, thrombolysis, clinical outcomes, stroke etiology, and radiological imaging.
KW - fibrin
KW - ischemic stroke
KW - leukocytes
KW - thrombectomy
KW - von Willebrand Factor
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U2 - 10.1161/STROKEAHA.121.034289
DO - 10.1161/STROKEAHA.121.034289
M3 - Review article
C2 - 34517770
AN - SCOPUS:85118579779
SN - 0039-2499
VL - 52
SP - 3718
EP - 3727
JO - Stroke
JF - Stroke
IS - 11
ER -