Study on the origin of major histocompatibility complex (MHC) genes in recombinant mouse strains by detection of polymorphic variants of MHC class III gene, complement C4.

A. Falus, C. S. David

Research output: Contribution to journalArticle

Abstract

In recombinant mouse strains the elements of the major histocompatibility complex gene cluster are composed of those of the parental strains. The origin of elements except the S region was previously determined by immunological and biochemical typing methods. For determination of the origin of the S region and the possible location of the recombination event around the S region, Southern blot analysis was performed. By the detection of genetic polymorphic patterns of complement C4 gene in 2 of the 5 recombinant strains the recombination was localized down-stream of the C4 gene and before the D gene region.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalActa Biochimica et Biophysica Hungarica
Volume24
Issue number1-2
StatePublished - 1989
Externally publishedYes

Fingerprint

Complement C4
Major Histocompatibility Complex
Genes
Genetic Recombination
Multigene Family
Southern Blotting

ASJC Scopus subject areas

  • Biochemistry

Cite this

@article{6ccbd3e0edbf412088cc8948a8639326,
title = "Study on the origin of major histocompatibility complex (MHC) genes in recombinant mouse strains by detection of polymorphic variants of MHC class III gene, complement C4.",
abstract = "In recombinant mouse strains the elements of the major histocompatibility complex gene cluster are composed of those of the parental strains. The origin of elements except the S region was previously determined by immunological and biochemical typing methods. For determination of the origin of the S region and the possible location of the recombination event around the S region, Southern blot analysis was performed. By the detection of genetic polymorphic patterns of complement C4 gene in 2 of the 5 recombinant strains the recombination was localized down-stream of the C4 gene and before the D gene region.",
author = "A. Falus and David, {C. S.}",
year = "1989",
language = "English (US)",
volume = "24",
pages = "165--170",
journal = "Ideggyogyaszati Szemle",
issn = "0019-1442",
publisher = "Ifjusagi Lap-es Konyvkiado Vallalat",
number = "1-2",

}

TY - JOUR

T1 - Study on the origin of major histocompatibility complex (MHC) genes in recombinant mouse strains by detection of polymorphic variants of MHC class III gene, complement C4.

AU - Falus, A.

AU - David, C. S.

PY - 1989

Y1 - 1989

N2 - In recombinant mouse strains the elements of the major histocompatibility complex gene cluster are composed of those of the parental strains. The origin of elements except the S region was previously determined by immunological and biochemical typing methods. For determination of the origin of the S region and the possible location of the recombination event around the S region, Southern blot analysis was performed. By the detection of genetic polymorphic patterns of complement C4 gene in 2 of the 5 recombinant strains the recombination was localized down-stream of the C4 gene and before the D gene region.

AB - In recombinant mouse strains the elements of the major histocompatibility complex gene cluster are composed of those of the parental strains. The origin of elements except the S region was previously determined by immunological and biochemical typing methods. For determination of the origin of the S region and the possible location of the recombination event around the S region, Southern blot analysis was performed. By the detection of genetic polymorphic patterns of complement C4 gene in 2 of the 5 recombinant strains the recombination was localized down-stream of the C4 gene and before the D gene region.

UR - http://www.scopus.com/inward/record.url?scp=0024811357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024811357&partnerID=8YFLogxK

M3 - Article

C2 - 2575314

AN - SCOPUS:0024811357

VL - 24

SP - 165

EP - 170

JO - Ideggyogyaszati Szemle

JF - Ideggyogyaszati Szemle

SN - 0019-1442

IS - 1-2

ER -