Study on a new IL-12 inducing gene NAP2

Min Yang, Na Liu, Adrian T. Ting

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

AIM: To study the function of newly cloned NF-kappaB-activating gene (NAP2) and its mechanism. METHEDS: Activation of NF-kappaB and IL-12 promoters as well as modulation of IL-12 synthesis by NAP2 in macrophages were observed by NF-kappaB and IL-12 luciferase reporter assay and intracellular IL-12 staining.

RESULTS: NAP2 could activate NF-kappaB and IL-12 promoter. But IkappaBalphaDN could inhibit their activation. In addition, NAP2 could induce IL-12 expression in macrophage cell line J774.

CONCLUSION: NAP2 as a newly cloned NF-kappaB activating gene can activate IL-12 promoter and induce IL-12 expression in macrophages. The data suggest that NAP2 regulates the expression of IL-12 most likely through its modulation of NF-kappaB transcription factor.

Original languageEnglish (US)
Pages (from-to)403-405
Number of pages3
JournalXi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Volume19
Issue number4
StatePublished - Jul 1 2003

ASJC Scopus subject areas

  • Medicine(all)

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