Studies of twins in vaccinology

Robert M. Jacobson, Inna G. Ovsyannikova, Paul V. Targonski, Gregory A. Poland

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In this survey, we review published investigations and trials of vaccines among twins. We identified 29 original studies, dating back to 1979. The studies include determinations of the role of genetics and environment in the variation in immune response to vaccination, the investigation of adverse events in which vaccination was the suspected etiologic agent, and the occurrence of vaccine preventable diseases or their complications. Specific methods include case reports, cross-sectional surveys, prospective surveys, and double-blind, randomized, placebo-controlled, cross-over studies. We examine three of these studies in detail to illustrate important opportunities and limitations of twins studies in vaccinology.

Original languageEnglish (US)
Pages (from-to)3160-3164
Number of pages5
JournalVaccine
Volume25
Issue number16 SPEC. ISS.
DOIs
StatePublished - Apr 20 2007

Fingerprint

Twin Studies
vaccine development
Vaccination
Vaccines
vaccination
vaccines
cross-sectional studies
Cross-Over Studies
placebos
Cross-Sectional Studies
Placebos
immune response
case studies
Surveys and Questionnaires
methodology
cross-over studies

Keywords

  • Twins
  • Vaccination
  • Vaccines

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Jacobson, R. M., Ovsyannikova, I. G., Targonski, P. V., & Poland, G. A. (2007). Studies of twins in vaccinology. Vaccine, 25(16 SPEC. ISS.), 3160-3164. https://doi.org/10.1016/j.vaccine.2007.01.048

Studies of twins in vaccinology. / Jacobson, Robert M.; Ovsyannikova, Inna G.; Targonski, Paul V.; Poland, Gregory A.

In: Vaccine, Vol. 25, No. 16 SPEC. ISS., 20.04.2007, p. 3160-3164.

Research output: Contribution to journalArticle

Jacobson, RM, Ovsyannikova, IG, Targonski, PV & Poland, GA 2007, 'Studies of twins in vaccinology', Vaccine, vol. 25, no. 16 SPEC. ISS., pp. 3160-3164. https://doi.org/10.1016/j.vaccine.2007.01.048
Jacobson RM, Ovsyannikova IG, Targonski PV, Poland GA. Studies of twins in vaccinology. Vaccine. 2007 Apr 20;25(16 SPEC. ISS.):3160-3164. https://doi.org/10.1016/j.vaccine.2007.01.048
Jacobson, Robert M. ; Ovsyannikova, Inna G. ; Targonski, Paul V. ; Poland, Gregory A. / Studies of twins in vaccinology. In: Vaccine. 2007 ; Vol. 25, No. 16 SPEC. ISS. pp. 3160-3164.
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