Studies of the homology of chromosomes between human being and rhesus monkey with chromosomal in situ suppression hybridization

Haojie Huang, X. Zhang, Y. Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chromosomal in situ suppression (CISS) hybridization of biotin-labeled DNA libraries for human chromosomes 1, 2 and 4 was used to investigate chromosome homology between human being and rhesus monkey. The results demonstrate that chromosome 1 in human being and rhesus monkey is homologous, of which the 1pter-->1q33 of rhesus monkey is highly homologous with a cognate region of chromosome 1 in human, while the 1q33-->1qter is relatively low; Chromosome 2 in human shows homology with the long arm of chromosome 13 as well as the long arm and the partial short arm of chromosome 9 in the rhesus, and chromosome 4 in human is identical to chromosome 2 in rhesus monkey. Combined with a comparative analysis of banding patterns of chromosomes, derivation relationships of chromosomes between man and the rhesus are discussed. Our present data provide a definitive proof that chromosomal rearrangements may be a major mechanism of chromosomal evolution in primates.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalActa Genetica Sinica
Volume20
Issue number3
StatePublished - 1993
Externally publishedYes

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Human Chromosomes
Macaca mulatta
In Situ Hybridization
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 4
Chromosomes
Chromosome Banding
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 9
Biotin
Gene Library
Primates

ASJC Scopus subject areas

  • Genetics

Cite this

Studies of the homology of chromosomes between human being and rhesus monkey with chromosomal in situ suppression hybridization. / Huang, Haojie; Zhang, X.; Chen, Y.

In: Acta Genetica Sinica, Vol. 20, No. 3, 1993, p. 193-200.

Research output: Contribution to journalArticle

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