Studies of primary central nervous system lymphoma with fluorine-18- fluorodeoxyglucose positron emission tomography

Steven Rosenfeld, J. M. Hoffman, R. E. Coleman, M. J. Glantz, M. W. Hanson, S. C. Schold

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Primary CNS lymphoma is a rare and highly malignant primary brain tumor. Ten patients with biopsy-proven primary CNS lymphoma were studied with 18F- 2-fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET) to demonstrate the findings in patients with this tumor. The accumulation of FDG in primary CNS lymphoma is similar to that seen in anaplastic gliomas and is significantly more prominent than in low grade astrocytomas (p = 0.001). Steroid therapy substantially reduced the amount of FDG uptake in the one case studied both before and after its administration. The difference in FDG uptake between steroid-treated and untreated cases of primary CNS lymphoma, however, did not reach statistical significance (p = 0.40). Primary CNS lymphoma, like gliomas, suppresses the metabolism of both contiguous and distant but functionally linked areas of the brain. This study thus shows that the metabolic behavior of primary CNS lymphoma, as monitored by FDG-PET, resembles that of malignant glial tumors.

Original languageEnglish (US)
Pages (from-to)532-536
Number of pages5
JournalJournal of Nuclear Medicine
Volume33
Issue number4
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Positron-Emission Tomography
Lymphoma
Central Nervous System
Glioma
Steroids
Astrocytoma
Brain Neoplasms
Neuroglia
Neoplasms
Biopsy
Brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Rosenfeld, S., Hoffman, J. M., Coleman, R. E., Glantz, M. J., Hanson, M. W., & Schold, S. C. (1992). Studies of primary central nervous system lymphoma with fluorine-18- fluorodeoxyglucose positron emission tomography. Journal of Nuclear Medicine, 33(4), 532-536.

Studies of primary central nervous system lymphoma with fluorine-18- fluorodeoxyglucose positron emission tomography. / Rosenfeld, Steven; Hoffman, J. M.; Coleman, R. E.; Glantz, M. J.; Hanson, M. W.; Schold, S. C.

In: Journal of Nuclear Medicine, Vol. 33, No. 4, 01.01.1992, p. 532-536.

Research output: Contribution to journalArticle

Rosenfeld, S, Hoffman, JM, Coleman, RE, Glantz, MJ, Hanson, MW & Schold, SC 1992, 'Studies of primary central nervous system lymphoma with fluorine-18- fluorodeoxyglucose positron emission tomography', Journal of Nuclear Medicine, vol. 33, no. 4, pp. 532-536.
Rosenfeld, Steven ; Hoffman, J. M. ; Coleman, R. E. ; Glantz, M. J. ; Hanson, M. W. ; Schold, S. C. / Studies of primary central nervous system lymphoma with fluorine-18- fluorodeoxyglucose positron emission tomography. In: Journal of Nuclear Medicine. 1992 ; Vol. 33, No. 4. pp. 532-536.
@article{5271f4bcd1334130b354dd94a185e20f,
title = "Studies of primary central nervous system lymphoma with fluorine-18- fluorodeoxyglucose positron emission tomography",
abstract = "Primary CNS lymphoma is a rare and highly malignant primary brain tumor. Ten patients with biopsy-proven primary CNS lymphoma were studied with 18F- 2-fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET) to demonstrate the findings in patients with this tumor. The accumulation of FDG in primary CNS lymphoma is similar to that seen in anaplastic gliomas and is significantly more prominent than in low grade astrocytomas (p = 0.001). Steroid therapy substantially reduced the amount of FDG uptake in the one case studied both before and after its administration. The difference in FDG uptake between steroid-treated and untreated cases of primary CNS lymphoma, however, did not reach statistical significance (p = 0.40). Primary CNS lymphoma, like gliomas, suppresses the metabolism of both contiguous and distant but functionally linked areas of the brain. This study thus shows that the metabolic behavior of primary CNS lymphoma, as monitored by FDG-PET, resembles that of malignant glial tumors.",
author = "Steven Rosenfeld and Hoffman, {J. M.} and Coleman, {R. E.} and Glantz, {M. J.} and Hanson, {M. W.} and Schold, {S. C.}",
year = "1992",
month = "1",
day = "1",
language = "English (US)",
volume = "33",
pages = "532--536",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "4",

}

TY - JOUR

T1 - Studies of primary central nervous system lymphoma with fluorine-18- fluorodeoxyglucose positron emission tomography

AU - Rosenfeld, Steven

AU - Hoffman, J. M.

AU - Coleman, R. E.

AU - Glantz, M. J.

AU - Hanson, M. W.

AU - Schold, S. C.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Primary CNS lymphoma is a rare and highly malignant primary brain tumor. Ten patients with biopsy-proven primary CNS lymphoma were studied with 18F- 2-fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET) to demonstrate the findings in patients with this tumor. The accumulation of FDG in primary CNS lymphoma is similar to that seen in anaplastic gliomas and is significantly more prominent than in low grade astrocytomas (p = 0.001). Steroid therapy substantially reduced the amount of FDG uptake in the one case studied both before and after its administration. The difference in FDG uptake between steroid-treated and untreated cases of primary CNS lymphoma, however, did not reach statistical significance (p = 0.40). Primary CNS lymphoma, like gliomas, suppresses the metabolism of both contiguous and distant but functionally linked areas of the brain. This study thus shows that the metabolic behavior of primary CNS lymphoma, as monitored by FDG-PET, resembles that of malignant glial tumors.

AB - Primary CNS lymphoma is a rare and highly malignant primary brain tumor. Ten patients with biopsy-proven primary CNS lymphoma were studied with 18F- 2-fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET) to demonstrate the findings in patients with this tumor. The accumulation of FDG in primary CNS lymphoma is similar to that seen in anaplastic gliomas and is significantly more prominent than in low grade astrocytomas (p = 0.001). Steroid therapy substantially reduced the amount of FDG uptake in the one case studied both before and after its administration. The difference in FDG uptake between steroid-treated and untreated cases of primary CNS lymphoma, however, did not reach statistical significance (p = 0.40). Primary CNS lymphoma, like gliomas, suppresses the metabolism of both contiguous and distant but functionally linked areas of the brain. This study thus shows that the metabolic behavior of primary CNS lymphoma, as monitored by FDG-PET, resembles that of malignant glial tumors.

UR - http://www.scopus.com/inward/record.url?scp=0026519430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026519430&partnerID=8YFLogxK

M3 - Article

C2 - 1552337

AN - SCOPUS:0026519430

VL - 33

SP - 532

EP - 536

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 4

ER -