Abstract
The polymorphics of two pericentric (GT) n sequences on the long arm of human chromosome 21 have been analyzed after PCR amplification, PAGE and Ag-staining for the first time in 50 Chinese Han people, and were used to detect meiotic origin of the extra chromosome 21 in Down syndromes. Six and 5 alleles were found in Chinese Han people for D21S215 and D21S120, respectively, with observed heterozigosities of 0.68 and polymorphic information content PIC, 0.67 and 0.65. For 17 Down syndromes whose parental origin of the extra chromosome 21 were known, meiotic origin of the extra chromosome 21 were determined in 16 cases, with 7 and 4 maternal meiosis I and II nondisjunction, 2 and 3 paternal meiosis I and II, respectively. The possible biological significance of the study on origin of the extra chromosome 21 has been discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 482-484 |
| Number of pages | 3 |
| Journal | Acta Genetica Sinica |
| Volume | 25 |
| Issue number | 6 |
| State | Published - 1998 |
Keywords
- Chromosome 21
- Down syndrome, (GT)n polymorphism
- Meiotic origin
- Nondisjunction
ASJC Scopus subject areas
- Molecular Biology
- Genetics