Structure-Based Identification of Natural-Product-Derived Compounds with Potential to Inhibit HIV-1 Entry

Medicine & Life Sciences

• Biological Products 67%
• HIV-1 59%
• Broadly Neutralizing Antibodies 48%
• HIV Fusion Inhibitors 37%
• Binding Sites 35%
• Inhibitory Concentration 50 20%
• HIV Envelope Protein gp120 17%
• HIV 15%
• Viruses 15%
• Hydrogen 13%
• Molecular Dynamics Simulation 12%
• Hydrophobic and Hydrophilic Interactions 12%
• Antiviral Agents 9%
• Proteins 8%
• Amino Acids 7%

Physics & Astronomy

• human immunodeficiency virus 100%
• entry 73%
• products 43%
• antibodies 24%
• envelopes 17%
• viruses 16%
• inhibitors 15%
• cells 14%
• proteins 10%
• lead compounds 10%
• interactions 8%
• amino acids 7%
• hydrogen 4%
• simulation 2%

Chemical Compounds

• Occurrence in Nature 56%
• Inhibitory Concentration 43%
• Amino-Acid Residue 30%
• Protein 28%
• Strain 23%
• Simulation 21%
• Hydrogen 17%