Abstract
The mechanism of DNA expansion is not well understood. Recent evidence from genetic, in vivo, and in vitro studies has suggested a link between the formation of alternative DNA secondary structures by trinucleotide repeat tracts and their propensity to undergo expansion. This review will focus on structural features and the mechanism of expansion relevant to human disease.
Original language | English (US) |
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Pages (from-to) | 325-336 |
Number of pages | 12 |
Journal | Biochemistry and Cell Biology |
Volume | 79 |
Issue number | 3 |
DOIs | |
State | Published - 2001 |
Keywords
- Expansion
- Hairpin
- Polymerase slippage
- Recombination
- Repair
- Trinucleotide repeat
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology