Structural features of trinucleotide repeats associated with DNA expansion

I. V. Kovtun, G. Goellner, C. T. McMurray

Research output: Contribution to journalShort survey

38 Scopus citations

Abstract

The mechanism of DNA expansion is not well understood. Recent evidence from genetic, in vivo, and in vitro studies has suggested a link between the formation of alternative DNA secondary structures by trinucleotide repeat tracts and their propensity to undergo expansion. This review will focus on structural features and the mechanism of expansion relevant to human disease.

Original languageEnglish (US)
Pages (from-to)325-336
Number of pages12
JournalBiochemistry and Cell Biology
Volume79
Issue number3
DOIs
StatePublished - Jan 1 2001

    Fingerprint

Keywords

  • Expansion
  • Hairpin
  • Polymerase slippage
  • Recombination
  • Repair
  • Trinucleotide repeat

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this