Structural exon database, SEDB, mapping exon boundaries on multiple protein structures

Chesley M. Leslin, Alexej Abyzov, Valentin A. Ilyin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Summary: Comparative analysis of exon/intron organization of genes and their resulting protein structures is important for understanding evolutionary relationships between species, rules of protein organization and protein functionality. We present Structural Exon Database (SEDB), with a Web interface, an application that allows users to retrieve the exon/intron organization of genes and map the location of the exon boundaries and the intron phase onto a multiple structural alignment. SEDB is linked with Friend, an integrated analytical multiple sequence/structure viewer, which allows simultaneous visualization of exon boundaries on structure and sequence alignments. With SEDB researchers can study the correlations of gene structure with the properties of the encoded three dimensional protein structures across eukaryotic organisms.

Original languageEnglish (US)
Pages (from-to)1801-1803
Number of pages3
JournalBioinformatics
Volume20
Issue number11
DOIs
StatePublished - Jul 22 2004
Externally publishedYes

Fingerprint

Protein Structure
Exons
Databases
Gene
Proteins
Genes
Protein
Introns
Sequence Alignment
Comparative Analysis
Alignment
Visualization
Three-dimensional
Research Personnel

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

Structural exon database, SEDB, mapping exon boundaries on multiple protein structures. / Leslin, Chesley M.; Abyzov, Alexej; Ilyin, Valentin A.

In: Bioinformatics, Vol. 20, No. 11, 22.07.2004, p. 1801-1803.

Research output: Contribution to journalArticle

Leslin, Chesley M. ; Abyzov, Alexej ; Ilyin, Valentin A. / Structural exon database, SEDB, mapping exon boundaries on multiple protein structures. In: Bioinformatics. 2004 ; Vol. 20, No. 11. pp. 1801-1803.
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