Abstract
Summary: Comparative analysis of exon/intron organization of genes and their resulting protein structures is important for understanding evolutionary relationships between species, rules of protein organization and protein functionality. We present Structural Exon Database (SEDB), with a Web interface, an application that allows users to retrieve the exon/intron organization of genes and map the location of the exon boundaries and the intron phase onto a multiple structural alignment. SEDB is linked with Friend, an integrated analytical multiple sequence/structure viewer, which allows simultaneous visualization of exon boundaries on structure and sequence alignments. With SEDB researchers can study the correlations of gene structure with the properties of the encoded three dimensional protein structures across eukaryotic organisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1801-1803 |
| Number of pages | 3 |
| Journal | Bioinformatics |
| Volume | 20 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jul 22 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Biochemistry
- Computer Science Applications
- Computational Theory and Mathematics
Cite this
Structural exon database, SEDB, mapping exon boundaries on multiple protein structures. / Leslin, Chesley M.; Abyzov, Alexej; Ilyin, Valentin A.
In: Bioinformatics, Vol. 20, No. 11, 22.07.2004, p. 1801-1803.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structural exon database, SEDB, mapping exon boundaries on multiple protein structures
AU - Leslin, Chesley M.
AU - Abyzov, Alexej
AU - Ilyin, Valentin A.
PY - 2004/7/22
Y1 - 2004/7/22
N2 - Summary: Comparative analysis of exon/intron organization of genes and their resulting protein structures is important for understanding evolutionary relationships between species, rules of protein organization and protein functionality. We present Structural Exon Database (SEDB), with a Web interface, an application that allows users to retrieve the exon/intron organization of genes and map the location of the exon boundaries and the intron phase onto a multiple structural alignment. SEDB is linked with Friend, an integrated analytical multiple sequence/structure viewer, which allows simultaneous visualization of exon boundaries on structure and sequence alignments. With SEDB researchers can study the correlations of gene structure with the properties of the encoded three dimensional protein structures across eukaryotic organisms.
AB - Summary: Comparative analysis of exon/intron organization of genes and their resulting protein structures is important for understanding evolutionary relationships between species, rules of protein organization and protein functionality. We present Structural Exon Database (SEDB), with a Web interface, an application that allows users to retrieve the exon/intron organization of genes and map the location of the exon boundaries and the intron phase onto a multiple structural alignment. SEDB is linked with Friend, an integrated analytical multiple sequence/structure viewer, which allows simultaneous visualization of exon boundaries on structure and sequence alignments. With SEDB researchers can study the correlations of gene structure with the properties of the encoded three dimensional protein structures across eukaryotic organisms.
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UR - http://www.scopus.com/inward/citedby.url?scp=4444255296&partnerID=8YFLogxK
U2 - 10.1093/bioinformatics/bth150
DO - 10.1093/bioinformatics/bth150
M3 - Article
C2 - 14988102
AN - SCOPUS:4444255296
VL - 20
SP - 1801
EP - 1803
JO - Bioinformatics
JF - Bioinformatics
SN - 1367-4803
IS - 11
ER -