TY - JOUR
T1 - Structural basis of efficient contagion
T2 - Measles variations on a theme by parainfluenza viruses
AU - Mateo, Mathieu
AU - Navaratnarajah, Chanakha K.
AU - Cattaneo, Roberto
N1 - Funding Information:
This work was funded by National Institutes of Health grants R01CA90636 , R01AI063476 and R01CA139389 . MM is a Merck fellow of the Life Sciences Research Foundation . CKN was a Kendall fellow of the Mayo Foundation . We thank Denis Gerlier, Iris Kemler, Yoshi Kawaoka, Thilo Stehle, and Steve Harrison for insightful comments on the manuscript, Martin Billeter for making a genetic approach to the study of MeV biology possible, and Jacques Ogg (Lyra Baroque Orchestra) for inspiration. Christian Pfaller and Grazia Isaya suggested La Rubeola (with apologies to Giuseppe Verdi) as title of a planned opera.
PY - 2014/4
Y1 - 2014/4
N2 - A quartet of attachment proteins and a trio of fusion protein subunits play the cell entry concert of parainfluenza viruses. While many of these viruses bind sialic acid to enter cells, wild type measles binds exclusively two tissue-specific proteins, the lymphatic receptor signaling lymphocytic activation molecule (SLAM), and the epithelial receptor nectin-4. SLAM binds near the stalk-head junction of the hemagglutinin. Nectin-4 binds a hydrophobic groove located between blades 4 and 5 of the hemagglutinin β-propeller head. The mutated vaccine strain hemagglutinin binds in addition the ubiquitous protein CD46, which explains attenuation. The measles virus entry concert has four movements. Andante misterioso: the virus takes over the immune system. Allegro con brio: it rapidly spreads in the upper airway's epithelia. 'Targeting' fugue: the versatile orchestra takes off. Presto furioso: the virus exits the host with thunder. Be careful: music is contagious.
AB - A quartet of attachment proteins and a trio of fusion protein subunits play the cell entry concert of parainfluenza viruses. While many of these viruses bind sialic acid to enter cells, wild type measles binds exclusively two tissue-specific proteins, the lymphatic receptor signaling lymphocytic activation molecule (SLAM), and the epithelial receptor nectin-4. SLAM binds near the stalk-head junction of the hemagglutinin. Nectin-4 binds a hydrophobic groove located between blades 4 and 5 of the hemagglutinin β-propeller head. The mutated vaccine strain hemagglutinin binds in addition the ubiquitous protein CD46, which explains attenuation. The measles virus entry concert has four movements. Andante misterioso: the virus takes over the immune system. Allegro con brio: it rapidly spreads in the upper airway's epithelia. 'Targeting' fugue: the versatile orchestra takes off. Presto furioso: the virus exits the host with thunder. Be careful: music is contagious.
UR - http://www.scopus.com/inward/record.url?scp=84893312377&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893312377&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2014.01.004
DO - 10.1016/j.coviro.2014.01.004
M3 - Review article
C2 - 24492202
AN - SCOPUS:84893312377
SN - 1879-6257
VL - 5
SP - 16
EP - 23
JO - Current Opinion in Virology
JF - Current Opinion in Virology
IS - 1
ER -