Stroke Prevention in Atrial Fibrillation and Other Major Cardiac Sources of Embolism

William D. Freeman, Maria I. Aguilar

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The frequency of cardioembolic stroke is expected to rise as the general population ages. Much of the increase may be attributed to atrial fibrillation, the most common cause of cardioembolic stroke and one that plays a substantial role in aging adults. Other sources of cardioembolic stroke may include ventricular thrombus from myocardial infarction, heart failure, structural heart defects such as patent foramen ovale (PFO), atrial septal aneurysm, proximal aortic atheroma, valvular heart disease, and endocarditis. Diagnostic studies, such as neuroimaging, ECG, and echocardiography, are helpful in uncovering cardioembolic sources of stroke. Medical therapy is predicated on the underlying mechanism. For example, warfarin may be indicated in certain patients who have atrial fibrillation, atrial, or ventricular thrombi, and PFO with atrial septal aneurysm and cryptogenic stroke in select young patients to prevent stroke. Newer diagnostic technologies, including multidetector CT and cardiac MRI, may be useful to diagnose cardiac causes of stroke when transesophageal echocardiography is indeterminate or cryptogenic stroke is present.

Original languageEnglish (US)
Pages (from-to)1129-1160
Number of pages32
JournalNeurologic Clinics
Volume26
Issue number4
DOIs
StatePublished - Nov 2008

Fingerprint

Embolism
Atrial Fibrillation
Stroke
Patent Foramen Ovale
Thrombosis
Heart Valve Diseases
Aortic Aneurysm
Transesophageal Echocardiography
Atherosclerotic Plaques
Warfarin
Endocarditis
Neuroimaging
Aneurysm
Echocardiography
Electrocardiography
Heart Failure
Myocardial Infarction
Technology
Population

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Stroke Prevention in Atrial Fibrillation and Other Major Cardiac Sources of Embolism. / Freeman, William D.; Aguilar, Maria I.

In: Neurologic Clinics, Vol. 26, No. 4, 11.2008, p. 1129-1160.

Research output: Contribution to journalArticle

Freeman, William D. ; Aguilar, Maria I. / Stroke Prevention in Atrial Fibrillation and Other Major Cardiac Sources of Embolism. In: Neurologic Clinics. 2008 ; Vol. 26, No. 4. pp. 1129-1160.
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