Stretching short biopolymers using optical tweezers

Yu Long Sun, Zong Ping Luo, Kai Nan An

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Optical tweezers is a useful technique to study single molecules. It has been applied to stretch biopolymers in several approaches. However, these approaches may not be appropriate to measure short biopolymers. In the present study, the optical signals of beads in different situations were studied. A new method was developed for stretching short biopolymers, as short as 300 nm in length. This new method was successfully applied to determine the stiffness of procollagen I molecules.

Original languageEnglish (US)
Pages (from-to)826-830
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume286
Issue number4
DOIs
StatePublished - Jan 1 2001

Keywords

  • Collagen
  • Optical tweezers
  • Short biopolymer
  • Single molecule

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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